Strep in Klaire's Therbiotics Complete

[Guest guest]

Further clarification on the CSB (Children with

Starving Brains) e-list question regarding the Strep

Thermophilus in Ther-Biotics from Ilene Buchholtz:

Dear Dr. McCandless,

I thought that you might find the following brief

summary regarding Streptococcus thermophilus of

interest. It provides a response to your recent

question asking if there was any potential adverse

interaction or cross reactivity between the probiotic

bacterium Streptococcus thermophilus and the Group A

ß-hemolytic streptococcal infection that is associated

with PANDAS (Pediatric Infection-Triggered Autoimmune

Neuropsychiatric Disorders). The answer was researched

by the doctors in our ProThera® and/Klaire Labs™

technical department and provided below with support

references. I believe that this information may have

some application to the concerns expressed yesterday

on the autism web groups about the use of S.

thermophilus.

A search of the medical literature reveals no evidence

of cross-reactivity between S. thermophilus and

pathogenic streptococcal species. Though belonging to

the same genus as disease-causing streptococci, an

examination of the genome of S. thermophilus reveals a

lack of the most important genetic determinants of

pathogenicity.1 Of note, one of these determinants, a

specific M protein (STM6P) found in group A

beta-hemolytic streptococci and to which autistic

children have demonstrated immune reactivity,2 is not

present in S. thermophilus3 suggesting it lacks the

important immunodominant epitopes expressed by

pathogenic streptococcal species. Also of significance

is the fact that PANDAS has never been associated with

the presence of streptococcal organisms outside of the

oropharyngeal cavity, for example on the skin or in

the intestinal tract.4 Further, there is evidence that

probiotic organisms such as S. thermophilus may

actually enhance immunity against pathogenic

streptococci. In one study, consumption of milk

cultured with S. thermophilus and other lactic acid

bacteria was found to reduce or eliminate the presence

of S. pneumoniae and beta-hemolytic streptococci in

the nasal cavities of study participants.5

While all of this evidence does not rule out the

possibility of cross-reactivity between non-pathogenic

and pathogenic species of streptococci, it provides

little or no basis for believing such cross-reactions

exist, and rather suggests that S. thermophilus may

have protective effects against colonization of

potentially harmful streptococcus organisms in the

upper respiratory tract.

References

1. Hols P, Hancy F, Fontaine L, et al. New insights

in the molecular biology and physiology of

Streptococcus thermophilus revealed by comparative

genomics. FEMS Microbiol Rev 2005;29:435-63.

2. Vojdani A, AW, Anyanwu E, et al.

Antibodies to neuron-specific antigens in children

with autism: possible cross-reaction with

encephalitogenic proteins from milk, Chlamydia

pneumoniae and Streptococcus group A. J Neuroimmunol

2002;129:168-77.

3. Universal Protein Resource (UniProt)

Knowledgebase; Protein Families; M Protein Family.

Universal Protein Resource (UniProt) Consortium

Website.

http://beta.uniprot.org/uniprot/?query=family:%22M+protein+family%22.

Accessed 2/29/08.

4. de Oliveira SK. PANDAS: a new disease? J Pediatr (

Rio J) 2007;83:201-8.

5. Glück U, Gebbers JO. Ingested probiotics reduce

nasal colonization with pathogenic bacteria

(Staphylococcus aureus, Streptococcus pneumoniae, and

beta-hemolytic streptococci). Am J Clin Nutr

2003;77:517-20.

I trust that this provides some further documentation

in support of using the S. thermophilus probiotic

strain with apparent safety and efficacy.

Sincere regards,

Ilene Buchholz, R.N.

Technical Product Specialist

Klaire Labs™, a division of ProThera®, Inc.

[Guest guest]

i'm sure this study though would also have been done on NT people and not

autistic people right?? I would think that would also make a difference, the

other thing to think about is that it's not the bacteria you are worring about

but the antibodies, which is what PANDAS would be reacting to, over replication

of antibodies to a NON bacteria- or non present issue. our kids bodies mix up

and mess up mix and soy protiens and milk protiens, or yeast and tetnus in

studies. (per Dr Shaws book) it would make for an interesting study.....adding

in or only changing this probotic and then weeks later measureing ASO titers, I

guess you would have to do pre and post....

Recovering from Autism is a marathon

NOT a sprint, but FULLY possible!

Read more about it on my Blogs at

http://www.myspace.com/christelking

Strep in Klaire's Therbiotics Complete

Further clarification on the CSB (Children with

Starving Brains) e-list question regarding the Strep

Thermophilus in Ther-Biotics from Ilene Buchholtz:

Dear Dr. McCandless,

I thought that you might find the following brief

summary regarding Streptococcus thermophilus of

interest. It provides a response to your recent

question asking if there was any potential adverse

interaction or cross reactivity between the probiotic

bacterium Streptococcus thermophilus and the Group A

ß-hemolytic streptococcal infection that is associated

with PANDAS (Pediatric Infection-Triggered Autoimmune

Neuropsychiatric Disorders). The answer was researched

by the doctors in our ProThera® and/Klaire LabsT

technical department and provided below with support

references. I believe that this information may have

some application to the concerns expressed yesterday

on the autism web groups about the use of S.

thermophilus.

A search of the medical literature reveals no evidence

of cross-reactivity between S. thermophilus and

pathogenic streptococcal species. Though belonging to

the same genus as disease-causing streptococci, an

examination of the genome of S. thermophilus reveals a

lack of the most important genetic determinants of

pathogenicity.1 Of note, one of these determinants, a

specific M protein (STM6P) found in group A

beta-hemolytic streptococci and to which autistic

children have demonstrated immune reactivity,2 is not

present in S. thermophilus3 suggesting it lacks the

important immunodominant epitopes expressed by

pathogenic streptococcal species. Also of significance

is the fact that PANDAS has never been associated with

the presence of streptococcal organisms outside of the

oropharyngeal cavity, for example on the skin or in

the intestinal tract.4 Further, there is evidence that

probiotic organisms such as S. thermophilus may

actually enhance immunity against pathogenic

streptococci. In one study, consumption of milk

cultured with S. thermophilus and other lactic acid

bacteria was found to reduce or eliminate the presence

of S. pneumoniae and beta-hemolytic streptococci in

the nasal cavities of study participants.5

While all of this evidence does not rule out the

possibility of cross-reactivity between non-pathogenic

and pathogenic species of streptococci, it provides

little or no basis for believing such cross-reactions

exist, and rather suggests that S. thermophilus may

have protective effects against colonization of

potentially harmful streptococcus organisms in the

upper respiratory tract.

References

1. Hols P, Hancy F, Fontaine L, et al. New insights

in the molecular biology and physiology of

Streptococcus thermophilus revealed by comparative

genomics. FEMS Microbiol Rev 2005;29:435-63.

2. Vojdani A, AW, Anyanwu E, et al.

Antibodies to neuron-specific antigens in children

with autism: possible cross-reaction with

encephalitogenic proteins from milk, Chlamydia

pneumoniae and Streptococcus group A. J Neuroimmunol

2002;129:168-77.

3. Universal Protein Resource (UniProt)

Knowledgebase; Protein Families; M Protein Family.

Universal Protein Resource (UniProt) Consortium

Website.

http://beta.uniprot.org/uniprot/?query=family:%22M+protein+family%22.

Accessed 2/29/08.

4. de Oliveira SK. PANDAS: a new disease? J Pediatr (

Rio J) 2007;83:201-8.

5. Glück U, Gebbers JO. Ingested probiotics reduce

nasal colonization with pathogenic bacteria

(Staphylococcus aureus, Streptococcus pneumoniae, and

beta-hemolytic streptococci). Am J Clin Nutr

2003;77:517-20.

I trust that this provides some further documentation

in support of using the S. thermophilus probiotic

strain with apparent safety and efficacy.

Sincere regards,

Ilene Buchholz, R.N.

Technical Product Specialist

Klaire LabsT, a division of ProThera®, Inc.

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