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thimerosal: HepB vaccine and developmental disability in US children aged 1–9 years

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H*epatitis B triple series vaccine and developmental disability in US

children aged 1–9 years*

Carolyn Gallagher and Melody Goodman

Toxicological & Environmental Chemistry

Vol. 90, No. 5, September–October 2008, 997–1008

This study investigated the association between vaccination with the

Hepatitis B

triple series vaccine prior to 2000 and developmental disability in

children aged 1–

9 years (n=1824), proxied by parental report that their child receives

early intervention or special education services (EIS). National Health and

Nutrition Examination Survey 1999–2000 data were analyzed and adjusted for

survey design by Linearization using SAS version 9.1 software,

with SAS

callable SUDAAN version 9.0.1. The odds of receiving EIS were approximately

nine times as great for vaccinated boys (n=46) as for unvaccinated boys

(n=7),

after adjustment for confounders. This study found statistically significant

evidence to suggest that boys in United States who were vaccinated with

the triple

series Hepatitis B vaccine, during the time period in which vaccines were

manufactured with thimerosal, were more susceptible to developmental

disability

than were unvaccinated boys.

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