Guest guest Posted December 8, 2008 Report Share Posted December 8, 2008 Wow! Imagine this! 46860 Topic: Nutritional Interventions May Benefit Children with Autism Keywords: AUTISM, NEUROBEHAVIORAL DISORDER - Nutrition, Methylcobalamin, Folinic Acid, Vitamin B, Glutathione Reference: " Efficacy of methylcobalamin and folinic acid treatment on glutathione redox status in children with autism, " SJ, Melnyk S, et al, Am J Clin Nutr, 2008 Dec 3; [Epub ahead of print]. (Address: Departments of Pediatrics and Biostatistics, University of Arkansas for Medical Sciences, Arkansas Children's Hospital Research Institute, Little Rock, AR, USA). Summary: In an open-label trial involving 40 autistic children, treatment with the metabolic precursors, methylcobalamin (75 mug/kg, 2 times/wk) and folinic acid (400 mug, 2 times/d) for a period of 3 months was found to significantly increase levels of cysteine, cysteinylglycine, and glutathione concentrations, as well as the glutathione redox ratio, and reduce the oxidized disulfide form of glutathione. At baseline, autistic children were found to have significantly lower levels of metabolite concentrations as compared to age-matched control children, and while the nutritional intervention improved these values in the autistic children, the levels remained lower than those found in the control children. The authors conclude, " The significant improvements observed in transmethylation metabolites and glutathione redox status after treatment suggest that targeted nutritional intervention with methylcobalamin and folinic acid may be of clinical benefit in some children who have autism. " Quote Link to comment Share on other sites More sharing options...
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