Re: 4 those on HT concerned about osteoporosis

[Guest guest]

I would be nervous about taking a bone building drug that lasts 6

months per dose. How do you stop that drug to do dental work? How

would you stop it quickly if you get that jaw disease from it, which

is something warned about all over the internet when you take any

Bisphophinate. I would be a concerned that it may be stronger than

Zometa, which may ruin your opportunity to get a short term PSA

response and temporary bone pain reduction out of Zometa when you

ultimately need it. Weekly Fosamax worked for me so I am sticking

with Fosamax. Doctors told me that any bone building med, whichever

one you pick, needs to be supported with exercise, Vit D, a little

calcium, a little sun, and a healthy diet to be successful.

>

> Amgen announced Denosumab, its experimental

> osteoporosis drug -- injected twice a year -- proved

> 40% superior to weekly Fosamax in improving bone

> density in the hip in a clinical trial.

>

>

>

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[Guest guest]

I was only 48 years old when I was diagnosed with prostate cancer,

and 49 when diagnosed with osteoporosis, but I already had

osteoporosis (with fractures) several years before I had the cancer.

I did a lot of tests to find out why I had osteoporosis, and an

endocrinologist said the root cause was low vit D over many years.

The comment I made about Zometa creating a brief PSA reduction and

bone pain reduction from first time use, came from MD cancer

center in Houston. I asked the oncology team there, why cant I go on

Zometa if it is considered a stronger bisphosphonate med than

Fosamax. I told them that another doctor I met with in Los Angeles

said that Zometa will build bone density faster than Fosamax. Md

answered and said I should stay on Fosamax and reserve

Zometa for the future when cancer progresses to the bone, because

they sometimes see a brief PSA response when they first administer

Zometa, and some bone pain reduction. That is where that comment came

from. I cannot validate that claim from experience because I have not

switched to Zometa yet. It took a long time, but Fosamax treated my

osteoporosis. The treatment started about 6 months before I started

HT and resolved the problem 2.5 years later. I am still taking

fosamax to maintain that bone density while on HT. Another doctor I

talked to at UCLA said a bone building med (he did not recommend one

in particular) should be used while on HT to prevent or treat

osteoporosis because it can delay mets to the bone. For what it is

worth, that is my experience with osteoporosis and some of the

comments doctors told me.

>

> > I would be nervous about taking a bone building drug that lasts 6

> > months per dose. How do you stop that drug to do dental work?

>

> The life of a bisphosphonate in bone is unknown.

>

> > How would you stop it quickly if you get that jaw disease from it,

> > which is something warned about all over the internet when you

take

> > any Bisphophinate.

>

> Once more, I have to say that bisphosphonates DO NOT CAUSE " jaw

> disease, " by which I suppose " allanbrandt " means osteonecrosis of

the jaw.

>

> The *cause* might be clumsy dental procedure, poor dental hygiene,

etc.

>

> I have attached a PDA, if anyone cares.

>

> > I would be a concerned that it may be stronger than Zometa, which

may

> > ruin your opportunity to get a short term PSA response and

temporary

> > bone pain reduction out of Zometa when you ultimately need it.

>

> I cannot fathom what " allanbrandt " means re: " opportunity to get a

short

> term PSA response. "

>

> So far as " temporary bone pain reduction " is concerned, the " label "

use

> of Zometa (and other such bisphosphonates) is palliative tx of bone

> metastases, which can be horribly painful.

>

> Regards,

>

> Steve J

>