Dietary oxidative stress and the potentiation of viral infection

[Guest guest]

Lots of relevance to regressive autism, especially when so-called

" attenuated " live viruses are injected into an infant or toddler with

elevated oxidative stress, eg, from suboptimal, intra-body

nutritional-status - eg, vaccinating a sick or recently sick infant, eg,

one who has or who had chronic diarrhea of infancy.

ps: Not free online

1: Annu Rev Nutr. 1998;18:93-116.

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Dietary oxidative stress and the potentiation of viral infection.

Beck MA, Levander OA.

Porter Graham Child Development Center, University of North

Carolina, Chapel Hill 27599-8180, USA. melinda_beck@...

Oxidative stress is implicated in the pathogenesis of several viral

infections, including hepatitis, influenza, and AIDS. Dietary

oxidative stress due to either selenium or vitamin E deficiency

increases cardiac damage in mice infected with a myocarditic strain

of coxsackievirus B3. Such dietary oxidative stress also allows a

normally benign (i.e., amyocarditic) coxsackievirus B3 to convert to

virulence and cause heart damage. This conversion to virulence is

due to a nucleotide sequence change in the genome of the benign

virus, which then resembles more closely the nucleotide sequence of

virulent strains. Although it has been known for many years that

poor nutrition can affect host response to infection, this is the

first report of host nutrition affecting the genetic sequence of a

pathogen. Further research is needed to determine whether poor host

nutrition plays any role in the emergence of new viral diseases via

alterations in he genotype of an infectious agent.

PMID: 9706220