malic acid conundrum: increasing absorption of aluminum - dietary factors including oxalic acid

[Guest guest]

,

Your concern seems valid. Malic acid is touted as a chelator of aluminum

(eg, 1-3), even as the abstract credits malic acid with contributing to

increased ingestion and increased brain concentrations of aluminum (4).

- - - -

Leon wrote:

I may be reading this wrong, but one statement in the study below " brain

aluminum concentrations were also raised by the intake of lactic, gluconic,

malic, citric, and oxalic acids " has me confused. I thought that Malic Acid

was used to RID the body of aluminum. This appears to say that Malic Acid

raises the concentration of Aluminum in the brain.

I think many of the kids are taking Malic Acid to actually chelate

Aluminum. Am I misreading this?

1. Malic Acid Aluminum toxicity may play a role in symptoms experienced

by magnesium-deficient ... However, the most potent; aluminum detoxifier

is malic acid. ...

http://www.healingwithnutrition.com/fdisease/fibromyalgia/magnesiumstudy.html

2. Malic Acid readily crosses the Blood-Brain-Barrier and has been shown

to bind to aluminum. It functions in the body by drawing aluminum away ...

http://www.vitanetonline.com/forums/1/Thread/134

3. Malic acid has been found to help remove the toxic metals lead,

strontium, and especially aluminum, among others. Your body manufactures

malic acid along ...

http://www.life-enhancement.com/article_template.asp?ID=509

4. Effect of various dietary constituents on gastrointestinal absorption

of aluminum from drinking water and diet.

Domingo JL, Gomez M, DJ, Llobet JM, Corbella J.

Res Commun Chem Pathol Pharmacol. 1993 Mar;79(3):377-80.

The influence of some frequent dietary constituents on gastrointestinal

absorption of aluminum from drinking water and diet was investigated in

mice. Eight groups of male mice received lactic (57.6 mg/kg/day),

tartaric (96 mg/kg/day), gluconic (125.4 mg/kg/day), malic (85.8

mg/kg/day), succinic (75.6 mg/kg/day), ascorbic (112.6 mg/kg/day),

citric (124 mg/kg/day), and oxalic (80.6 mg/kg/day) acids in the

drinking water for one month. At the end of this period, animals were

killed and aluminum concentrations in liver, spleen, kidney, brain, and

bone were determined. All the dietary constituents significantly

increased the aluminum levels in bone, whereas brain aluminum

concentrations were also raised by the intake of lactic, gluconic,

malic, citric, and oxalic acids. The levels of aluminum found in spleen

were significantly increased by gluconic and ascorbic acids, whereas

gluconic and oxalic acids also raised the concentrations of aluminum

found in kidneys. Because of the wide presence and consumption of the

above dietary constituents, in order to prevent aluminum accumulation

and toxicity we suggest a drastic limitation of human exposure to aluminum.

PMID: 8480083

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