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Re:Can PSA go down?

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I recommend Terry's article on PSA for basic information

and will add a bit to what he said concerning the specific

question of whether PSA can go down.

The answer is, Yes. PSA can go down.

If the PSA is elevated due to a temporary stress on the

prostate, the PSA can come down if the stress is reduced.

Stress can be due to ejaculation, physical pressure,

infections of various types, calcium or other solid

deposits, injuries, and probably other factors.

Some drugs will reduce PSA. These include the finasteride

/ dutasteride drugs (e.g., Proscar, Avodart), and drugs that

interfere with testosterone production or uptake (Lupron,

Casodex, etc.)

PSA can also be reduced if more cancer cells die than

are reproduced. This could, for example, be due to

chemotherapy and may play a significant role in the

androgen deprivation drugs mentioned above.

Some other factors that are thought to possibly

increase cancer cell deaths and hence reduce PSA might

be the kinds of diets that Laurel mentioned, or to

various supplements such as pomegranate extract,

vitamin D, vitamin C, and who knows what. The evidence

for all of these is not as conclusive as we would like.

Finally, as Terry points out, PSA varies a lot from

time to time for unknown reasons. Obviously, something

causes this variation. But no one yet knows what.

Alan

Alan Meyer

ameyer2@...

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