Re: Monthly update...and next steps

[Guest guest]

,

I am doing DES now it’s working, putting

off the chemo as long as I can. QOL has improved greatly – better mood

and no hot flushes J. Caused breast

growth and weight gain – used RT and smaller portions. Dose is 1 mg daily

with aspirin.

Short stats:

Dx Dec 1999 baseline PSA 220,

Gleason 7, T4, bone mets.

Tx Zoladex, PSA nadir 0.3. Casodex added July 2006. Stop Casodex

July 2007. PSA 30.1 Sept 2007 Start DES, bone scan clear. PSA 22 Dec 2007,

Original tumour invading bladder. Palliative RT. Fosamax since 2001.

From:

ProstateCancerSupport

[mailto:ProstateCancerSupport ] On Behalf Of Emerson

Sent: 31 January 2008 03:52

To: hrpca group; PCa Under Yahoo

Group; PPML List; Yahoo PCaGroup

Subject:

Monthly update...and next steps

My

monthly PSA came back earlier today an it rose again and now stands at 36

My Oncologist recommended I stop High Dose Keto and Hydrocortizone at once in

anticipation

of next steps. Chemo (if we choose this path) would require for me to be off

Keto.

I have an appointment with a doc at University of Kansas Medical Center on

Friday to discuss

potential trails or other second line therapies.

I have an appointment next Tuesday for new CT and Bone scans as well.

So, your thoughts on what's next?

> Should I try DES or Estrogen Patches now or do Chemo now and use these as

a step after Chemo?

> Should I do anything while I wait until late March to see Dr. Myers?

--

Emerson

www.flhw.org

Historical Numbers

Date

- PSA

1/28/08 36.2

12/31/07 30.9

12/3/07 21.9

11/5/07 23.3

10/8/07

19.30

>10/8/07

Changed Lupron from 120 day dose to monthly dose

>

9-12-07 Began taking .5mg of Avodart per day. Changed Ketoconazole

from 600mg twice per day to 400mg three times per day)

9/4/07 21.80

8/6/07 19.25

8/2/07 16.96

7/02/07 20.30

6/04/07 17.80

4/30/07 16.25

4/2/07 17.68

3/5/07 21.87

2/5/07 20.90

1/8/07 18.90

12/11/06 24.86

11/13/06 43.61

10/16/06 51.48 (Started " High Dose " Ketoconazole and Hydrocortisone,

10/01)[at this point and for a second time we prepared for Taxotere. First my

Oncologist wanted to try High Dose Ketoconazole and Hydrocortisone.]

9/11/06 83.97 (started Zometa)

8/23/06 41.77

8/18/06 54.66(no tests in June or July)

5/19/06 11.37 (stopped Casodex)

4/3/06 4.25

3/5/06 1.45 (started Casodex again)

1/27/06 0.46

12/28/05 1.85[at this point we prepared for Taxotere, chemotherapy treatments.

First I had a new PSA test and new bone and CT scans, lymph nodes clear, spine

clear, ribs, femur and hips stable. The PSA dropped to 1.85 and the scans

revealed marked improvement. Chemo was cancelled 72 hours before it was

scheduled to begin]

12/15/05 7.18

11/03/05 4.64 (Stopped taking Casodex)

9/22/05 0.8

08/11/05 0.35

6/24/05 0.55

4/17/05 2.51 (taken at MD , Gleason lowered to 7/7)

4/06/05 3.51 (Six weeks after starting Lupron and Casodex)Original Gleason

scores (7/8)Pre-treatment test:

2/?/05 219

12/?/04 189 (Original test)

[Guest guest]

Good to know

I'm gald for both of us that the DES started working.

We are at the moment discussing when to go on to DES and what to put with it. Hearing Case Notes on BBC Radio 4 some of the NSAIDs (not aspirin) show an increase in heart problems, though aspirin may not be the best for my stomach. The registrar at York is consulting a haematologist about me. He said there is great discussion in Yorkshire about when to put men on DES varying views up to PSA of 40. I'm at 7 at the moment and I don't think I want to be up at 40 as I had a 3cm tumour by then a few years ago. I negotiated a couple of PSA tests over the next 4 months to see what the Dublin time is (Sorry doubling time).

Hope things continue well.

PS I already have the boobs after being on Casodex 150mg

Monthly update...and next steps

My monthly PSA came back earlier today an it rose again and now stands at 36My Oncologist recommended I stop High Dose Keto and Hydrocortizone at once in anticipationof next steps. Chemo (if we choose this path) would require for me to be off Keto.I have an appointment with a doc at University of Kansas Medical Center on Friday to discusspotential trails or other second line therapies.I have an appointment next Tuesday for new CT and Bone scans as well.So, your thoughts on what's next?> Should I try DES or Estrogen Patches now or do Chemo now and use these as a step after Chemo?> Should I do anything while I wait until late March to see Dr. Myers?-- Emersonwww.flhw.orgHistorical NumbersDate - PSA1/28/08 36.212/31/07 30.912/3/07 21.911/5/07 23.3 10/8/07 19.30 >10/8/07 Changed Lupron from 120 day dose to monthly dose> 9-12-07 Began taking .5mg of Avodart per day. Changed Ketoconazole from 600mg twice per day to 400mg three times per day)9/4/07 21.808/6/07 19.258/2/07 16.967/02/07 20.306/04/07 17.804/30/07 16.254/2/07 17.683/5/07 21.872/5/07 20.901/8/07 18.9012/11/06 24.8611/13/06 43.6110/16/06 51.48 (Started "High Dose" Ketoconazole and Hydrocortisone, 10/01)[at this point and for a second time we prepared for Taxotere. First my Oncologist wanted to try High Dose Ketoconazole and Hydrocortisone.]9/11/06 83.97 (started Zometa)8/23/06 41.778/18/06 54.66(no tests in June or July)5/19/06 11.37 (stopped Casodex)4/3/06 4.253/5/06 1.45 (started Casodex again)1/27/06 0.4612/28/05 1.85[at this point we prepared for Taxotere, chemotherapy treatments. First I had a new PSA test and new bone and CT scans, lymph nodes clear, spine clear, ribs, femur and hips stable. The PSA dropped to 1.85 and the scans revealed marked improvement. Chemo was cancelled 72 hours before it was scheduled to begin]12/15/05 7.1811/03/05 4.64 (Stopped taking Casodex)9/22/05 0.808/11/05 0.356/24/05 0.554/17/05 2.51 (taken at MD , Gleason lowered to 7/7)4/06/05 3.51 (Six weeks after starting Lupron and Casodex)Original Gleason scores (7/8)Pre-treatment test:2/?/05 21912/?/04 189 (Original test)

[Guest guest]

Hi Dear,

The hormone ablation will most probably cause his PSA to

go down. Many oncologists would keep your husband on

the hormone therapy for about a year. Then he could go

off therapy and see if the PSA remains undetectable. If

so he would not need any further therapy.

If it were me, I would not have the surgery. This would

just add more unpleasant side effects to his problems.

Please get a second or even a third opinion from an

oncologist who specializes in prostate cancer.

I wish you all the bestAubrey Pilgrim, DC (Ret.) Author ofA Revolutionary Approach to Prostate Cancer-Read the original book for FREE at: http://www.prostatepointers.org/prostate/lay/apilgrim/Read new edition for FREE at http://www.cancer.prostate-help.org/capilgr.htmDr. E. Crawford is co-author of the revision

I stated my husband had no choice but surgery. We went for a second opinion his PSA 7.9 and Gleason #9. We saw the specialist ranked the second best prostate cancer doctor in New England.They told us his stage was hard to rank but closest to T2 aggressive. My husband has to have a bone scan to make sure the cancer hasn't spread to the bone. He will start Hormonal Therapy that day Casadex. Then one injection a month for three months. The doctor told us this will stop the cancer from growing and shrink the prostate. After three months he will have the surgery and then the pathologist will determine if he has to have radiation. My husband is very comfortable with this treatment. Just thought I'd let the group know what was going on. Plus my husband wanted his own doctor and the specialist said he could have both of them for all the treatment. He's thrilled with this option.Start the year off right. Easy ways to stay in shape in the new year.