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Re: Dosing T3

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Val

What happens if we take it right after meal?less absorbed?

bw

nil

Re: Dosing T3

It is the same as any thyroid med. Take it an hour before or two hours after eating or you can take it sublingually to avoid the food conflicts. I usually take mine sublingually thne it doesnt; matter eating too close to dosing a I had to diose 4 tim4es a day for best results.

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My understanding is that T3 is 95% absorbed regardless of stomach

contents, empty or full. T4 however needs stomach acid.

Steve

wrote:

> It is the same as any thyroid med. Take it an hour before or two hours

> after eating or you can take it sublingually to avoid the food

> conflicts. I usually take mine sublingually thne it doesnt; matter

> eating too close to dosing a I had to diose 4 tim4es a day for best results.

>

--

Steve - dudescholar4@...

Take World's Smallest Political Quiz at

http://www.theadvocates.org/quiz.html

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to truth we must still march on. " --Stopford

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> My understanding is that T3 is 95% absorbed regardless of stomach

> contents, empty or full. T4 however needs stomach acid.

> Steve

I sure hope this is the final word. I have found that I need to dose

T3 more frequently than 4x a day. It is really hard to work around

meals on an every 2 hrs schedule.

I don't know if anyone else has found this. I tried a couple of days

ago to dose less frequently and found I needed more HC. I am much more

level there with smaller doses.

Dorothy

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wrote:

> That is good news but I had nver read that before. My docs have always

> told me i tis the same for anything med thta food interferes with

> absorptin.

>

Here is the deal on T3 and T4 absorption according to drugs.com. Just

for clarity for those that are not aware, Levothyroxine is T4 and

Liothyronine Sodium is T3. The information isn't as clear as I would

like but with or without food, absorption of T3 appears to be 95%. The

half life is also quite long compared to the multi day dosing that often

is par for the course on these lists. I know I've been taking T3 three

times a day but am planing to switch to twice a day over time. The half

life for T3 varies depending on if one is hypo, euthyroid, or hyper with

euthyroid resulting in a half life for T3 of 24 hours.

http://www.drugs.com/mmx/liothyronine-sodium.html

Absorption:

Oral:

Levothyroxine: Incomplete and variable, especially when taken with food;

average 50 to 75% {13}.

Liothyronine: Approximately 95% {08}.

Note: Absorption may be reduced in patients with congestive heart

failure, malabsorption syndromes, or diarrhea {13}.

Protein binding:

Very high (more than 99%), but not firmly bound {01} {08} {13}.

Biotransformation:

As for endogenous thyroid hormone; levothyroxine (approximately 30%

{09}) is deiodinated in peripheral tissues; small amounts are

metabolized in the liver and excreted in bile.

Half-life:

Levothyroxine:

Euthyroid: 6 to 7 days.

Hypothyroid: 9 to 10 days.

Hyperthyroid: 3 to 4 days.

Liothyronine:

Euthyroid: 1 day.

Hypothyroid: 1.4 days.

Hyperthyroid: 0.6 day.

Note: Because thyroid and thyroglobulin contain varying amounts of

thyroxine and triiodothyronine, their half-lives will vary but will be

somewhere between that for T 4 and T 3.

Time to peak therapeutic effect

With chronic stable oral dosing:

Levothyroxine, thyroglobulin, thyroid: 3 to 4 weeks.

Liothyronine: 48 to 72 hours {01}.

--

Steve - dudescholar4@...

Take World's Smallest Political Quiz at

http://www.theadvocates.org/quiz.html

" If a thousand old beliefs were ruined on our march

to truth we must still march on. " --Stopford

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Tell me again why you don't take your T3 sublingually or buccally?

sol

dorothyroeder wrote:

> this is the final word. I have found that I need to dose

> T3 more frequently than 4x a day. It is really hard to work around

> meals on an every 2 hrs schedule.

>

> I don't know if anyone else has found this. I tried a couple of days

> ago to dose less frequently and found I needed more HC. I am much more

> level there with smaller doses.

>

> Dorothy

>

>

> ------------------------------------

>

>

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