UroToday - Dietary Modification in Patients With Prostate Cancer on Active Surveillance: A randomized, Multicentre Feasibility Study - Abstract

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Friday, 22 February 2008

s Comprehensive Cancer Center, University of California San Diego, La

Jolla, CA, USA.

Roswell Park Cancer Institute, Buffalo, NY, USA.

To evaluate the feasibility of implementing a diet-based intervention in men

with prostate cancer on active surveillance, as changes in diet might

potentially inhibit the progression of prostate cancer.

As part of the Men's Eating and Living (MEAL) Study (a multicentre pilot

trial of a diet-based intervention for prostate cancer) 43 men aged 50-80

years with prostate cancer and on active surveillance were randomized to

receive either telephone-based dietary counselling or standardized, written

nutritional information. Telephone counselling targets included increased

intakes of vegetables (particularly cruciferous vegetables and tomato

products), whole grains, and beans/legumes. Dietary intakes and plasma

carotenoid levels were assessed at baseline and at after 6 months.

In the intervention arm the mean daily intakes of total vegetables,

crucifers and tomato products increased by 71%, 180% and 265%, respectively

(P < 0.05); in the control arm there were no significant changes in mean

intakes of these components. Similarly, in the intervention arm, mean plasma

levels of alpha-carotene, beta-carotene, lutein, lycopene and total

carotenoids increased by 37%, 32%, 23%, 30% and 25%, respectively (P <

0.05); in the control arm there were no significant changes in plasma levels

of these components. There were no significant changes in either group in

whole grain, beans/legumes, or fat intake.

Telephone-based dietary counselling increases vegetable intake and plasma

concentrations of potentially anticarcinogenic carotenoids in men with

prostate cancer on active surveillance. These data support the feasibility

of implementing clinical trials of diet-based interventions in this

population.

Written by

Parsons JK, Newman VA, Mohler JL, Pierce JP, Flatt S, Marshall J.

Reference

BJU Int. 2008 Jan 24. Epub ahead of print.

PubMed Abstract

PMID:18218061