UroToday - Intensifying the Saturation Biopsy Technique for Detecting Prostate Cancer after Previous Negative Biopsies: A Step in the Wrong Direction - Abstract

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Friday, 21 March 2008

Department of Urology, University of Ulm, Ulm, and Krankenhaus

Göttingen-Weende, Göttingen, Germany.

To report the results using an extensive saturation biopsy in men with

negative prostate biopsies but in whom there is still a clinical suspicion

for carcinoma.

Between February 1999 and October 2004 we offered 40 patients (median age 63

years) an extensive saturation biopsy if there was clinical suspicion of

prostate cancer after previous negative prostate biopsies. The median

(range) number of cores taken was 64 (39-139) and was adjusted to the size

of the prostate. All patients received general or spinal anaesthesia.

Of the 40 patients, 18 (45%) had carcinoma in at least one core; 16 had a

radical prostatectomy, which showed pT2a, pT2b, pT2c, pT3a and pT3b

adenocarcinoma of the prostate in three, four, six, two and one patients,

respectively. Brachytherapy and external radiation were the therapies of

choice in the other patients. Sixteen patients had marked haematuria after

the biopsy procedure.

There is no significant increase in the cancer detection rate in an

extensive saturation-biopsy regimen compared to published series with fewer

cores, but the morbidity increased.

Written by

Simon J, Kuefer R, Bartsch G Jr, Volkmer BG, Hautmann RE, Gottfried HW.

Reference

BJU Int. 2008 Mar 5. Epub ahead of print.

doi:10.1111/j.1464-410X.2008.07560.x

PubMed Abstract

PMID:18325061