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PLS & dementia

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I knew there was another PLS article that mentioned

something about dementia (other than " no dementia " ).

Here's the abstract:

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Neurology 1995 Nov;45(11):2005-9

Primary lateral sclerosis: a neuropsychological study.

Caselli RJ, BE, Osborne D Department of

Neurology, Mayo Clinic sdale, AZ 85259, USA.

Nine patients with clinically diagnosed,

radiologically supported primary lateral sclerosis

underwent cognitive testing. None was demented, but

eight had mild cognitive impairment. Performances were

most consistently impaired on neuropsychological tests

sensitive to frontal lobe functions, followed by tests

sensitive to memory. Cognitive testing may be useful

in helping to establish a cortical localization in

patients with the syndrome of progressive spasticity.

There are potential nosologic relations between

primary lateral sclerosis and other degenerative

frontal lobe syndromes, such as frontal lobe dementia

and progressive spasticity with dementia.

PMID: 7501149, UI: 96063524

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Incidentally, abstracts of PLS articles in medical

journals can be quickly found at

http://www4.ncbi.nlm.nih.gov/PubMed/ Type in the

words " primary lateral sclerosis " in quotes (otherwise

you'll get hundreds of useless abstracts) and hit " GO " .

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