Fw: Emailing: Detection of toluenediamines in the urine of a patient with polyurethane-covered breast implants -- Chan et al. 37 (5) 756 -- Clinical Chemistry

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I knew Dr. Sui Chan and he found TDA in my urine. We have lost him; however, he might have died. We plan on finding out what happened to him...he was on our side.

Love always.......Lea

~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~``

Sent: Sunday, December 17, 2006 10:30 AM

Subject: Emailing: Detection of toluenediamines in the urine of a patient with polyurethane-covered breast implants -- Chan et al. 37 (5) 756 -- Clinical Chemistry

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Perform your original search, [authors] Chan intitle Detection of toluenediamines in the urine of a patient ..., in Clinical Chemistry SearchClinical Chemistry 37: 756-758, 1991;

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Clinical Chemistry, Vol 37, 756-758, Copyright © 1991 by American Association for Clinical Chemistry

Detection of toluenediamines in the urine of a patient with polyurethane-covered breast implants

SC Chan, DC Birdsell and CY Gradeen Department of Laboratory Medicine, Foothills Hospital, Calgary, Alberta, Canada. Breast prostheses are implanted for augmentation or during reconstructive surgery. One of the more commonly used prostheses is the polyurethane-sponge-covered silicone gel implant. Some clinicians are concerned about the safety of this product because the polyurethane foam disintegrates in vivo, and its subsequent fate is not known. Polyurethane is a polymer formed by reacting diisocyanates and polyols. This study indicates that the polymer sponge breaks down into its reactive monomers, 2,4- and 2,6-toluenediisocyanate, which are converted into their corresponding diamines. We present evidence of the excretion of the diamine metabolites in the urine of a patient implanted with polyurethane-covered prostheses.

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W.-J. Hu, J. W. Eaton, T. P. Ugarova, and L. TangMolecular basis of biomaterial-mediated foreign body reactionsBlood, August 15, 2001; 98(4): 1231 - 1238. [Abstract] [Full Text] [PDF]

V. , M. Jayabalan, and S. SandhyaStudies on Polyurethane Potting Compound Based on Isocyanurate of Aliphatic Diisocyanate for Fabrication of a HaemodialyserJ Biomater Appl, October 1, 2000; 15(2): 86 - 105. [Abstract] [PDF]

L. Tang, T. A. Jennings, and J. W. EatonMast cells mediate acute inflammatory responses to implanted biomaterialsPNAS, July 21, 1998; 95(15): 8841 - 8846. [Abstract] [Full Text] [PDF]

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TABLE OF CONTENTSCopyright © 1991 by the American Association for Clinical Chemistry.