Re: Re: info on treatment studies

[Guest guest]

Bindi . . . I'd like to know more about how to search PubMed . . . Granted, I wouldn't be able to access the latest research - but I'd settle for the rest if it's not too out of date! Rogene

[Guest guest]

Rogene,

Basically you just go to the site and search like you would on google. It's very easy.

I wanted to tell you that I have been reading a lot about MCP, or modified citrus pectin. It has been studied and found to be a good heavy metal chelator, detoxifier, as well as a preventative for cancer. I take it every day-- it sure tastes yucky. Below is some info and a link to a study using MCP for preventing cancer.

Bindi

Modified Citrus pectin has been shown to attach to cancer cells to prevent them from spreading throughout the bodyPectin is a complex carbohydrate (polysaccharide) found in virtually all plants. Pectin helps to bind cells together and provides a structural framework for maintaining the shape and integrity of cell membranes. Recently, a modified form of citrus pectin derived from the pulp and peel of citrus fruits has been shown to attach to cancer cells to prevent them from spreading throughout the body, pointing the way to a potentially safe approach for preventing or reducing cancer metastases. Dosage: Start with 1 teaspoon (5 grams) daily.Gradually increase to 2-3 teaspoons daily or as recommended by your health care professional. For daily maintenance 1/2-1 teaspoon can be used. Mix in a blender with 8 oz of water juice or other liquid and drink immediately.Spreading MetastasesConventional cancer treatment involves surgery to remove primary tumors, followed by chemotherapy, radiation, or a combination of treatments designed to eradicate all remaining traces of cancer. This follow-up therapy is critical for addressing the biggest threat from cancer—the formation of secondary cancers, or metastases. Metastases are not new or different cancers, but new cancer colonies started from cells that have migrated to new sites. Sites where metastases commonly occur include the bones, lungs, prostate, kidney, liver, thyroid and brain. Left unchecked, metastases can quickly overwhelm the body’s defenses. In fact, it is metastases, not primary tumors that are responsible for most cancer deaths. Halting MetastasesOver the last two decades, research into controlling or halting cancer metastases has led to two promising new strategies. The first, antiangiogenesis, targets the growth of new blood vessels (angiogenesis) that are required for tumor growth. Originally pioneered by noted cancer researcher Dr. Judah Folkman, antiangiogenesis grew from his observation that tumors cannot grow without access to a constant supply of new blood vessels. Folkman theorized that cancer cells actively communicate with surrounding tissues to trigger the growth of new blood vessels (neovascularization) needed to supply nutrients and remove waste products. Once neovascularization is initiated, hundreds of new capillaries converge on the tumor site and are quickly coated with new layers of rapidly dividing tumor cells. Folkman also theorized that, just as certain chemical messengers can initiate new capillary formation, other signals could inhibit neovascularization. This insight led to the development of antiangiogenic therapy, which, in contrast to other cancer treatments, doesn’t directly destroy tumors, but aims to limit their blood supply, causing tumors to shrink. By 1997 researchers were excited by promising results from several antiangiogenic drugs. Speaking of one early angiogenesis inhibitor called TNP470, in 1997 Folkman commented on the results of early clinical human trials, stating, “We’ve not seen a tumor that we cannot regress (shrink).” Currently TNP470 and several other angiogenesis inhibitors are in clinical trials, and other promising compounds are under study in university laboratories and in some 30 pharmaceutical and biotechnology companies around the world. For more information on nutritional compounds that have been shown to help inhibit new capillary growth and reduce angiogenesis refer to “Nutritional Support for Cellular Mutagenic Concerns,” in the June 2003 issue of Vitamin Research News. Intercepting Cancer CellsThe second strategy for controlling metastases works by intercepting migrating cancer cells before they have a chance to establish new tumors. This approach targets a family of carbohydrate-binding proteins called lectins. Lectins are attracted to sugar molecules found on the surface of almost all cells. Lectins help cancer cells stick together to form multi-celled clusters that are believed to be necessary for metastases formation. Lectins also enable cancer cells to communicate with each other, as well as with other types of cells (cell-to-cell communication) to trigger cellular transformations that assist the spread of cancer. One class of lectin—called galectins (for galactoside-binding lectins)—possesses an especially strong affinity for galactose, a simple sugar located on the surface of cells lining blood vessels. A number of cancer researchers have focused on a particular galectin—galectin-3—that has been found to be directly involved in the progression and spread of several types of cancers, including breast, prostate and colon cancer. Serum levels of galectin-3 correlate closely with the spread of cancer, and may serve as a biological marker to help physicians and patients monitor the efficacy of anti-cancer therapies. The Protein-Sugar ConnectionThe powerful attraction between galectins and galactose plays a pivotal role in how cancers spread in the body. After a cancer cell has broken free from its primary tumor (or is accidentally dislodged during surgery) it floats freely through the blood and lymph systems until it eventually becomes trapped in a small blood vessel (microcapillary). Firmly lodged in the microcapillary, galectins on the surface of the cancer cell start to bind to galactose receptors on endothelial cells (the cells that form the inside lining of blood vessels). After securely attaching to the endothelium the cancer cells penetrate through the blood vessel walls. The final step after invading the vessel involves the release of chemical signals that trigger new blood vessel growth (angiogenesis), and a new tumor colony is firmly established. Modified Citrus PectinModified citrus pectin (MCP) is a unique dietary fiber that is produced by processing natural citrus pectin by altering its pH and splitting the carbohydrate chains to form a low molecular-weight, water-soluble fiber that is rich in the sugar, galactose. It is this presence of particularly high amounts of galactose that led researchers to wonder if MCP might bind with proteins (lectins) on cancer cells to inhibit their ability to bind with other tissues. Early test tube studies revealed that MCP did indeed bind to galectins from numerous human cancer cell lines to inhibit their ability to adhere to other cells. Researchers found that as little as a 1.0 percent solution of MCP inhibited attachment of 1) human prostate adenocarcinoma cells, 2) human breast carcinoma cells, 3) human melanoma cells, and 4) human laryngeal epidermoid carcinoma cells to human endothelial cells. (Naik H, et al.) In 1992, Platt and colleagues demonstrated that MCP was effective at reducing metastases in mice injected with live melanoma cells. One group of mice was injected with normal melanoma cells, while a second group received melanoma cells that had been incubated in a solution containing MCP. Seventeen days after being injected, the mice receiving untreated melanoma cells were found to have, on average, 33 new tumors (metastases) in their lungs, while the mice receiving the MCP-treated cells had virtually no lung tumors. The researchers hypothesized that MCP had successfully attached to the lectin sites on the cancer cells, blocking the receptors and rendering them incapable of attaching to other cells. In a second study conducted in 1995, Pienta and colleagues demonstrated that adding MCP to drinking water was an effective delivery route for reducing experimental metastases in rats. Four days after injecting rats with live prostate cancer cells, the animals were divided into three groups. Two groups of rats were treated with MCP added to their drinking water in amounts of 0.1% and 1.0%. The animals in the third group, the control, received no MCP. Thirty days after being injected with one million active prostate cancer cells, 15 out of 16 rats in the control (untreated) group had cancer metastases in their lungs, compared with 7 of 14 rats in the 0.1% group, and 9 of 16 in the 1.0% group. Importantly, the 1.0% group had, on average, only one tumor per animal, versus an average of nine tumors in the lungs of the control group. Commenting on the results of the study the researchers noted that oral intake of modified citrus pectin acts as a “potent inhibitor of spontaneous prostate cancer metastasis

Supplement Facts

1 Teaspoon (5 grams)

Serving Per Container: 40

Amount Per Serving

% Daily Value

Modified Citrus Pectin

5

g

*

*Daily Value not established

Contains no added sugar starch salt wheat gluten corn coloring flavoring or dairy products.Keep container tightly closed in a cool dry and dark place. Keep out of reach of children.

http://jncicancerspectrum.oxfordjournals.org/cgi/content/abstract/jnci%3b94/24/1854

Re: Re: info on treatment studies

Bindi . . .

I'd like to know more about how to search PubMed . . . Granted, I wouldn't be able to access the latest research - but I'd settle for the rest if it's not too out of date!

Rogene

[Guest guest]

One of the things my oncologist admitted (after I quizzed him) is that we all have cancer cells scattered throughout our bodies . . . For my benefit, he called them dormat. (there's probaby a medical term for that state). These cancer cells become active when triggered by something . . . that "something" isn't well understood. It only makes sense that, if we continually work at keeping toxins out of our bodies, and provide our bodies with a healthy lifestyle, that our chances of developing cancer are reduced. With all the chemicals in today's environment, it's tough! Rogene

[Guest guest]

True! I saw a video on the health channel in . It was about the FDA wanting to know exactly what we put in our bodies...if I remember correctly. Anyway, so they got this one guy and tested him. He said they drew 14 vials of blood! Ends up that he had 164 different toxins and mercury in his body!!! Wow....just...wow.Rogene S <saxony01@...> wrote: One of the things my oncologist admitted (after I quizzed him) is that we all have cancer cells scattered throughout our bodies . .

.. For my benefit, he called them dormat. (there's probaby a medical term for that state). These cancer cells become active when triggered by something . . . that "something" isn't well understood. It only makes sense that, if we continually work at keeping toxins out of our bodies, and provide our bodies with a healthy lifestyle, that our chances of developing cancer are reduced. With all the chemicals in today's environment, it's tough! Rogene

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[Guest guest]

There is a really interesting article in this month's National Geographic about the toxic chemical levels in our bodies. We all have them, no matter how healthy we are, but I think one can surely try and keep the levels as low as possible.

Bindi

Re: Re: info on treatment studies

True! I saw a video on the health channel in . It was about the FDA wanting to know exactly what we put in our bodies...if I remember correctly. Anyway, so they got this one guy and tested him. He said they drew 14 vials of blood! Ends up that he had 164 different toxins and mercury in his body!!! Wow....just...wow.Rogene S <saxony01 > wrote:

One of the things my oncologist admitted (after I quizzed him) is that we all have cancer cells scattered throughout our bodies . . . For my benefit, he called them dormat. (there's probaby a medical term for that state). These cancer cells become active when triggered by something . . . that "something" isn't well understood.

It only makes sense that, if we continually work at keeping toxins out of our bodies, and provide our bodies with a healthy lifestyle, that our chances of developing cancer are reduced. With all the chemicals in today's environment, it's tough!

Rogene

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