Re: Nicotinamide: So Far So Good . . .

[Guest guest]

Hey all,

I just wanted to add a comment/update. I've been taking the Source

Naturals B Coenzyme Complex (with NAD in it) for almost a year now,

and so far so good. I haven't had a real MS attack since June 2006.

I adapted to the benzodiazepine-like effects that I talked about with

the NAD and driving. I am fairly used to it by now and do just fine.

I also notice that I can handle winter weather much better with the

increased energy (and on downside it has caused me to gain a little

weight).

I haven't gone for an MRI in quite a while. I'll have to go soon and

let you all know how it looks, but I'm cautiously optimistic.

This year I was under tons of stress at work, was abusing my body

working tons of overtime and very little sleep (4.5 hours average),

so all in all the Nicotinamide seems to be positive, so far so good.

I also take my Copaxone daily, SAM-e every other day or so, and

occasionally Padma 28, Vitamin E, and Vitamin D.

I AM NOT A DOCTOR. CONSULT A REAL PHYSICIAN BEFORE CHANGING ANYTHING

IN YOUR CURRENT REGIMINE. TAKE ANY SUPPLEMENTS AT YOUR OWN RISK!!!

Cheers,

>

> I AM NOT A DOCTOR. CONSULT A REAL PHYSICIAN BEFORE CHANGING

ANYTHING

> IN YOUR CURRENT REGIMINE. TAKE ANY SUPPLEMENTS AT YOUR OWN RISK!!!

>

> Hi all,

>

> I've been trying Nicotinamide the past few weeks. I am confused as

to

> the tradeoffs between benefit and side effects.

>

> I believe that Nicotinamide and its brother Niacinimide may both be

> anti-anxiety and hypnotic in a way similar to benzodiazepine:

>

> " Niacinamide has also been found to stimulate GABA receptors,

without

> binding to the receptor sites, thus creating a benzodiazepine-like

> effect "

>

> http://www.findarticles.com/p/articles/mi_m0FDN/is_6_7/ai_96416605?

>

lstpn=article_results & lstpc=search & lstpr=external & lstprs=other & lstwid=

> 1 & lstwn=search_results & lstwp=body_middle

>

> http://www.benzoliberty.com/information/comingoff.php

>

> I felt these effects to an extent that I felt impaired when driving

> ( . . . I ran a few red lights.) Just passing on the warning.

>

> Also, these same effects seemed to impair my short term memory in a

> pattern similar to the cognitive symptoms of Muliple Sclerosis. Is

> the nicotinamide causing MS inflammation? Or is it just an innocent

> side effect?

>

> It's hard to be certain. However, on the positive side, my energy

has

> been increased dramatically, my erectile dysfunction went away,

> numbness went away, my self-confidence and sense of well being went

> up dramatically. Consequently, I don't want to stop taking it.

>

> However, I did stop for a while out of initial fear of my driving

> being too impaired. I noticed that it stayed in my system for

several

> days even after I stopped taking it, and eating things like rice

> (which is high in B vitamins) seemed to trigger its effects again.

> Alcohol and/or other supplements also may have enhanced its effects

> (benzodiazepine is a nervous system depressant, I believe).

>

> Thus, I am cautiously optimistic. I need an MRI to see what's going

> on in my brain. I also may need to find the right balance/dosage

> where my daily life is not impaired but the benefit is still there.

>

> Anyone else have any experiences with Nicotinamide (NAD)??? I am

> taking the Source Naturals B Coenzyme Complex with NAD in it. I

> preferred that personally over the straight NADH.

>

> If anyone else has experimented with Nicotinamide please send me an

> email at prendebp@... noting your experiences, if possible.

>

> Thanks,

> from Chicago

>

[Guest guest]

What is NAD? I did a search and can't find it. Does anyone know?

If there is something that has a natural benzodiazepine effect, I

would be very interested in it. The reason for that is that

occasionally when I have' taken Xanax, it seems to help quite a bit

with my numbness and with the film feeling over one of my eyes, and

even a little with stiffness. But I don't want to take Xanax, so a

natural alternative that has a benzodiazapene effect would be great.

..

> >

> > I AM NOT A DOCTOR. CONSULT A REAL PHYSICIAN BEFORE CHANGING

> ANYTHING

> > IN YOUR CURRENT REGIMINE. TAKE ANY SUPPLEMENTS AT YOUR OWN RISK!!!

> >

> > Hi all,

> >

> > I've been trying Nicotinamide the past few weeks. I am confused

as

> to

> > the tradeoffs between benefit and side effects.

> >

> > I believe that Nicotinamide and its brother Niacinimide may both

be

> > anti-anxiety and hypnotic in a way similar to benzodiazepine:

> >

> > " Niacinamide has also been found to stimulate GABA receptors,

> without

> > binding to the receptor sites, thus creating a benzodiazepine-

like

> > effect "

> >

> >

http://www.findarticles.com/p/articles/mi_m0FDN/is_6_7/ai_96416605?

> >

>

lstpn=article_results & lstpc=search & lstpr=external & lstprs=other & lstwid=

> > 1 & lstwn=search_results & lstwp=body_middle

> >

> > http://www.benzoliberty.com/information/comingoff.php

> >

> > I felt these effects to an extent that I felt impaired when

driving

> > ( . . . I ran a few red lights.) Just passing on the warning.

> >

> > Also, these same effects seemed to impair my short term memory in

a

> > pattern similar to the cognitive symptoms of Muliple Sclerosis.

Is

> > the nicotinamide causing MS inflammation? Or is it just an

innocent

> > side effect?

> >

> > It's hard to be certain. However, on the positive side, my energy

> has

> > been increased dramatically, my erectile dysfunction went away,

> > numbness went away, my self-confidence and sense of well being

went

> > up dramatically. Consequently, I don't want to stop taking it.

> >

> > However, I did stop for a while out of initial fear of my driving

> > being too impaired. I noticed that it stayed in my system for

> several

> > days even after I stopped taking it, and eating things like rice

> > (which is high in B vitamins) seemed to trigger its effects

again.

> > Alcohol and/or other supplements also may have enhanced its

effects

> > (benzodiazepine is a nervous system depressant, I believe).

> >

> > Thus, I am cautiously optimistic. I need an MRI to see what's

going

> > on in my brain. I also may need to find the right balance/dosage

> > where my daily life is not impaired but the benefit is still

there.

> >

> > Anyone else have any experiences with Nicotinamide (NAD)??? I am

> > taking the Source Naturals B Coenzyme Complex with NAD in it. I

> > preferred that personally over the straight NADH.

> >

> > If anyone else has experimented with Nicotinamide please send me

an

> > email at prendebp@ noting your experiences, if possible.

> >

> > Thanks,

> > from Chicago

> >

>

[Guest guest]

NAD is a biochemistry thing

NADH and FADH2 are the major electron carriers in the oxidation of

fuel molecules. This is used to turn ADP into ATP, our cells basic

form of energy. I'm not sure if we took it as an oral presentation if

it would make it into our cells or not?

http://en.wikipedia.org/wiki/Nicotinamide_adenine_dinucleotide

I remember hearing the song " it aint me " and pretended they were

singing " N " " A " " D " . I won't quit my day job.

There is a link on wikipedia about " nicotinamide " that sounds more

like an ad than learning molecule function.

> > >

> > > I AM NOT A DOCTOR. CONSULT A REAL PHYSICIAN BEFORE CHANGING

> > ANYTHING

> > > IN YOUR CURRENT REGIMINE. TAKE ANY SUPPLEMENTS AT YOUR OWN RISK!!!

> > >

> > > Hi all,

> > >

> > > I've been trying Nicotinamide the past few weeks. I am confused

> as

> > to

> > > the tradeoffs between benefit and side effects.

> > >

> > > I believe that Nicotinamide and its brother Niacinimide may both

> be

> > > anti-anxiety and hypnotic in a way similar to benzodiazepine:

> > >

> > > " Niacinamide has also been found to stimulate GABA receptors,

> > without

> > > binding to the receptor sites, thus creating a benzodiazepine-

> like

> > > effect "

> > >

> > >

> http://www.findarticles.com/p/articles/mi_m0FDN/is_6_7/ai_96416605?

> > >

> >

> lstpn=article_results & lstpc=search & lstpr=external & lstprs=other & lstwid=

> > > 1 & lstwn=search_results & lstwp=body_middle

> > >

> > > http://www.benzoliberty.com/information/comingoff.php

> > >

> > > I felt these effects to an extent that I felt impaired when

> driving

> > > ( . . . I ran a few red lights.) Just passing on the warning.

> > >

> > > Also, these same effects seemed to impair my short term memory in

> a

> > > pattern similar to the cognitive symptoms of Muliple Sclerosis.

> Is

> > > the nicotinamide causing MS inflammation? Or is it just an

> innocent

> > > side effect?

> > >

> > > It's hard to be certain. However, on the positive side, my energy

> > has

> > > been increased dramatically, my erectile dysfunction went away,

> > > numbness went away, my self-confidence and sense of well being

> went

> > > up dramatically. Consequently, I don't want to stop taking it.

> > >

> > > However, I did stop for a while out of initial fear of my driving

> > > being too impaired. I noticed that it stayed in my system for

> > several

> > > days even after I stopped taking it, and eating things like rice

> > > (which is high in B vitamins) seemed to trigger its effects

> again.

> > > Alcohol and/or other supplements also may have enhanced its

> effects

> > > (benzodiazepine is a nervous system depressant, I believe).

> > >

> > > Thus, I am cautiously optimistic. I need an MRI to see what's

> going

> > > on in my brain. I also may need to find the right balance/dosage

> > > where my daily life is not impaired but the benefit is still

> there.

> > >

> > > Anyone else have any experiences with Nicotinamide (NAD)??? I am

> > > taking the Source Naturals B Coenzyme Complex with NAD in it. I

> > > preferred that personally over the straight NADH.

> > >

> > > If anyone else has experimented with Nicotinamide please send me

> an

> > > email at prendebp@ noting your experiences, if possible.

> > >

> > > Thanks,

> > > from Chicago

> > >

> >

>