Guest guest Posted September 25, 2001 Report Share Posted September 25, 2001 Ian, thanks. Actually, I had injected iodine contrast, but each time (4 times now in the past 3 years) I have had injected contrast, I have also had the metallic taste in my mouth and upset stomach for 24 hours. Must be something about the way my body reacts to most drugs, I guess. They used a IV port (?) first then put the contrast into that, so no problems with the veins that I am aware of. I had no idea how much iodine we were talking about with the contrast. This is the first time I have been clear on the scale of what we are talking about. No wonder we're talking about avoidance if at all possible! This discussion line has been very helpful to me and I assume to others in the same position. I have had two endocrine specialists in my journey so far and both thought 6 weeks to 2 months was all that was required to ensure the contrast cleared sufficiently for RAI. (Both surgeons also repeated the same information to me withint the past week!) The current endocrinologist recommends LID and is at least open to the possibility he is wrong at this point, so I have a chance at a successful RAI when the contrast clears. Thanks. > Hi Judy > > I'm sorry, wasn't able to reply before now. > > As far as I am aware, the problems with iodine based contrast relate to the > sheer quantity of iodine present, and the possibility of it being 'tissued'. > There may be other reasons. > > You talk about the taste of the contrast, so I assume that you were given an > oral version. To put things in context, one oral contrast (Conray = > Meglumine) is given in doses of 60 to 100ml, with each ml containing 370mg of > iodine. That is a total of 22 to 37 GRAMS of iodine, about half a million > times the recommended maximum intake of 50 micrograms per day on the LID. > > Virtually all of this will be excreted in a very short time, BUT: no drug can > be 100% pure. There WILL be iodinated impurities present, and these may be > excreted quite slowly and unpredictably. > > Also, for those who receive your contrast by injection, a trace may be left > in the tissue at the injection site, especially if the injection went badly > or if you have poor veins. This trace may take a long time to clear. > > There are probably other factors of which I am unaware. > > As far as the body is concerned, free iodide from the contrast, from your > vitamins or from the RAI are indistinguishable. I think that you were trying > to saturate your thyroid with dietary iodine to prevent contrast iodine doing > the same thing. I can't honestly see any point. Sorry. > > Ian Ian Adam > Radiation Safety Officer > The Institute of Cancer Research > Cotswold Road > Sutton > Surrey > SM2 5NG > Tel: 020 8722 4250 > Fax: 020 8722 4300 > EMail: iana@i... Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 27, 2001 Report Share Posted September 27, 2001 Hi Alyssa Extravasation (outside the vein) is the proper word for 'tissueing'. Contrast doesn't move through tissue very quickly, so tissued contrast will stay for ages. Ian > If there was " extravisation " (I think that's what they called it) when > they put the iodine dye in via IV for a CT with contrast, does that make > it even worse as far as the iodine staying longer in my system than if > they IV had worked right and it had gone into the vein. About 100 cc > went into the tissues of my arm instead of into the vein. My doctor > said scanning 6 weeks later was OK and didn't do 24 hour urine test. > > Ian Adam wrote: > > > > Hi Judy > > > > I'm sorry, wasn't able to reply before now. > > > > As far as I am aware, the problems with iodine based contrast relate > > to the > > sheer quantity of iodine present, and the possibility of it being > > 'tissued'. > > There may be other reasons. > > > > You talk about the taste of the contrast, so I assume that you were > > given an > > oral version. To put things in context, one oral contrast (Conray = > > Meglumine) is given in doses of 60 to 100ml, with each ml containing > > 370mg of > > iodine. That is a total of 22 to 37 GRAMS of iodine, about half a > > million > > times the recommended maximum intake of 50 micrograms per day on the > > LID. > > > > Virtually all of this will be excreted in a very short time, BUT: no > > drug can > > be 100% pure. There WILL be iodinated impurities present, and these > > may be > > excreted quite slowly and unpredictably. > > > > Also, for those who receive your contrast by injection, a trace may be > > left > > in the tissue at the injection site, especially if the injection went > > badly > > or if you have poor veins. This trace may take a long time to clear. > > > > There are probably other factors of which I am unaware. > > > > As far as the body is concerned, free iodide from the contrast, from > > your > > vitamins or from the RAI are indistinguishable. I think that you were > > trying > > to saturate your thyroid with dietary iodine to prevent contrast > > iodine doing > > the same thing. I can't honestly see any point. Sorry. > > > > Ian > > > > > So as I sit here with the metallic taste of iodine contrast in my > > > mouth, I am still curious whether anyone has any idea whether my > > > pre-CT scan strategy for combatting this was sound or might have a > > > chance of working: > > > > > > 1) I ate as much on the LID iodine " no-no " list as possible; that > > > spicy/salty Mexican beef, smothered with cheese and sour cream sure > > > tasted good! > > > > > > 2) I got a " stress relief " vitamin with 165 mcg of iodine, 110% of > > the > > > daily value, and took two servings yesterday (220%) and one this > > > morning four hours before my CT scan for a total of 330 percent (495 > > > > > mcg) of daily value in 24 hours, along with my dietary intake, of > > > course. > > > > > > Since so many of us end up with iodine contrast before RAI, is there > > > > > any reason to hope that feeding the thyroid cells will minimize the > > > contrast uptake and reduce the risk of rendering the RAI > > ineffective? > > > > > > Since I'm in Minnesota and Mayo does the urine iodine tests, I > > figure > > > a few of those (and a few additional LID weeks) are in my future > > > prior to agreeing to another RAI. > > > > > > I've checked the archives and can finding nothing on pre-feeding > > > iodine. > > > > > > Judy > > > > > > > > > > > > > > > > > > > > > > > > > > > For more information regarding thyroid cancer visit www.thyca.org. > > If you do not wish to belong to this group, you may UNSUBSCRIBE by > > sending a blank email to thyca-unsubscribe > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
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