Acetaminophen use after measles-mumps-rubella(MMR) vaccination was associated with autistic disorder.

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Acetaminophen use after measles-mumps-rubella vaccination was associated with

autistic disorder.

Acetaminophen (paracetamol) use, measles-mumps-rubella vaccination, and autistic

disorder: The results of a parent survey .    Schultz ST , Klonoff-Cohen HS,

Wingard DL, Akshoomoff NA, Macera CA , Ming Ji .

University of California San Diego , and San Diego State University , USA .

.schultz@... .

The present study was performed to determine whether acetaminophen (paracetamol)

use after the measles-mumps-rubella vaccination could be associated with

autistic disorder. This case-control study used the results of an online

parental survey conducted from 16 July 2005 to 30 January 2006 , consisting of

83 children with autistic disorder and 80 control children.

 

Acetaminophen use after measles-mumps-rubella vaccination was significantly

associated with autistic disorder when considering children 5 years of age or

less (OR 6.11, 95% CI 1.42-26.3), after limiting cases to children with

regression in development (OR 3.97, 95% CI 1.11-14.3), and when considering only

children who had post-vaccination sequelae (OR 8.23, 95% CI 1.56-43.3),

adjusting for age, gender, mother's ethnicity, and the presence of illness

concurrent with measles-mumps-rubella vaccination. Ibuprofen use after

measles-mumps-rubella vaccination was not associated with autistic disorder.

This preliminary study found that acetaminophen use after measles-mumps-rubella

vaccination was associated with autistic disorder.

PMID: 18445737 [PubMed - in process