Guest guest Posted September 25, 2006 Report Share Posted September 25, 2006 http://www.medicinenet.com/script/main/art.asp?articlekey=64251 Vitamin B3 May Help MS Mouse Study: Vitamin B3 Protects Brain Cells -- Even in Late-Stage Multiple Sclerosis By DeNoon WebMD Medical News Reviewed By Louise Chang, MD on Tuesday, September 19, 2006 Sept. 19, 2006 -- The newest treatment for multiple sclerosis might be vitamin B3 , mouse studies suggest. Nicotinamide is a form of vitamin B3 closely related to niacin. In a mouse model of MS, nicotinamide protects brain cells from degeneration. Given in the early stages of disease, it offered "dramatic protection." Given in late disease, it protected against further brain damage and new disease symptoms, report Shinjiro Kaneko, MD, and colleagues at Children's Hospital, Boston. Both effects would be welcomed by people with MS. Current MS treatments work only in the early "relapsing-remitting" phase of the disease. Nothing currently slows the devastating later "chronic progressive" stage of MS. "The earlier therapy was started, the better the effect, but we hope nicotinamide can help patients who are already in the chronic stage," Kaneko said, in a news release. "We hope that our work will initiate a clinical trial, and that nicotinamide could be used in real patients." Kaneko and colleagues report their findings in the Sept. 20 issue of the Journal of Neuroscience. Nerve Fiber Protection During multiple sclerosis, nerve fibers -- axons -- are damaged by self-destructive immune responses. It's possible, Kaneko and colleagues suggest, that protecting them from further damage could slow disease -- or even lead to some recovery. The researchers noticed that in the mouse model of MS, the axons of mice with hyperactive Wld genes aren't damaged as easily. The Wld gene, it turns out, makes an enzyme necessary for the production of another protein called NAD. Kaneko and colleagues found that as mice progress to MS disease, nerve levels of NAD decline. Kaneko and colleagues tried treating MS mice with nicotinamide. NAD can be formed from nicotinamide. They found that this prevented the decline of NAD -- and protected axons from disease. "We demonstrate that administering nicotinamide can … result in profound neuroprotection in [the mouse model of MS], providing a novel therapeutic possibility for MS patients," Kaneko and colleagues conclude. Of course, clinical trials will be needed to find out if vitamin B3 really can be a safe and effective treatment for multiple sclerosis. SOURCES: Kaneko, S. Journal of Neuroscience, Sept. 20, 2006; vol 26, manuscript received ahead of publication. News release, Children's Hospital, Boston. © 2006 WebMD Inc. All rights reserved. Right now I'm having amnesia and deja vu at the same time.. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 5, 2006 Report Share Posted October 5, 2006 It's a good thing I'm taking my B-50's! 50 mg per capsule and I take two a day. Okay, okay, so I've not been good about taking my supplements lately... except my morning SAMe! LOLOL But it's there, when I might remember to take it! Hey, I'll go dot hat right now. LOL Challis Sharon Marsden wrote: http://www.medicinenet.com/script/main/art.asp?articlekey=64251 Vitamin B3 May Help MS Mouse Study: Vitamin B3 Protects Brain Cells -- Even in Late-Stage Multiple Sclerosis By DeNoonWebMD Medical News Reviewed By Louise Chang, MDon Tuesday, September 19, 2006 Sept. 19, 2006 -- The newest treatment for multiple sclerosis might be vitamin B3 , mouse studies suggest. Nicotinamide is a form of vitamin B3 closely related to niacin. In a mouse model of MS, nicotinamide protects brain cells from degeneration. Given in the early stages of disease, it offered "dramatic protection." Given in late disease, it protected against further brain damage and new disease symptoms, report Shinjiro Kaneko, MD, and colleagues at Children's Hospital, Boston. Both effects would be welcomed by people with MS. Current MS treatments work only in the early "relapsing-remitting" phase of the disease. Nothing currently slows the devastating later "chronic progressive" stage of MS. "The earlier therapy was started, the better the effect, but we hope nicotinamide can help patients who are already in the chronic stage," Kaneko said, in a news release. "We hope that our work will initiate a clinical trial, and that nicotinamide could be used in real patients." Kaneko and colleagues report their findings in the Sept. 20 issue of the Journal of Neuroscience. Nerve Fiber Protection During multiple sclerosis, nerve fibers -- axons -- are damaged by self-destructive immune responses. It's possible, Kaneko and colleagues suggest, that protecting them from further damage could slow disease -- or even lead to some recovery. The researchers noticed that in the mouse model of MS, the axons of mice with hyperactive Wld genes aren't damaged as easily. The Wld gene, it turns out, makes an enzyme necessary for the production of another protein called NAD. Kaneko and colleagues found that as mice progress to MS disease, nerve levels of NAD decline. Kaneko and colleagues tried treating MS mice with nicotinamide. NAD can be formed from nicotinamide. They found that this prevented the decline of NAD -- and protected axons from disease. "We demonstrate that administering nicotinamide can … result in profound neuroprotection in [the mouse model of MS], providing a novel therapeutic possibility for MS patients," Kaneko and colleagues conclude. Of course, clinical trials will be needed to find out if vitamin B3 really can be a safe and effective treatment for multiple sclerosis. SOURCES: Kaneko, S. Journal of Neuroscience, Sept. 20, 2006; vol 26, manuscript received ahead of publication. News release, Children's Hospital, Boston. © 2006 WebMD Inc. All rights reserved. Right now I'm having amnesia and deja vu at the same time.. All-new Yahoo! Mail - Fire up a more powerful email and get things done faster. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 5, 2006 Report Share Posted October 5, 2006 It's a good thing I'm taking my B-50's! 50 mg per capsule and I take two a day. Okay, okay, so I've not been good about taking my supplements lately... except my morning SAMe! LOLOL But it's there, when I might remember to take it! Hey, I'll go dot hat right now. LOL Challis Sharon Marsden wrote: http://www.medicinenet.com/script/main/art.asp?articlekey=64251 Vitamin B3 May Help MS Mouse Study: Vitamin B3 Protects Brain Cells -- Even in Late-Stage Multiple Sclerosis By DeNoonWebMD Medical News Reviewed By Louise Chang, MDon Tuesday, September 19, 2006 Sept. 19, 2006 -- The newest treatment for multiple sclerosis might be vitamin B3 , mouse studies suggest. Nicotinamide is a form of vitamin B3 closely related to niacin. In a mouse model of MS, nicotinamide protects brain cells from degeneration. Given in the early stages of disease, it offered "dramatic protection." Given in late disease, it protected against further brain damage and new disease symptoms, report Shinjiro Kaneko, MD, and colleagues at Children's Hospital, Boston. Both effects would be welcomed by people with MS. Current MS treatments work only in the early "relapsing-remitting" phase of the disease. Nothing currently slows the devastating later "chronic progressive" stage of MS. "The earlier therapy was started, the better the effect, but we hope nicotinamide can help patients who are already in the chronic stage," Kaneko said, in a news release. "We hope that our work will initiate a clinical trial, and that nicotinamide could be used in real patients." Kaneko and colleagues report their findings in the Sept. 20 issue of the Journal of Neuroscience. Nerve Fiber Protection During multiple sclerosis, nerve fibers -- axons -- are damaged by self-destructive immune responses. It's possible, Kaneko and colleagues suggest, that protecting them from further damage could slow disease -- or even lead to some recovery. The researchers noticed that in the mouse model of MS, the axons of mice with hyperactive Wld genes aren't damaged as easily. The Wld gene, it turns out, makes an enzyme necessary for the production of another protein called NAD. Kaneko and colleagues found that as mice progress to MS disease, nerve levels of NAD decline. Kaneko and colleagues tried treating MS mice with nicotinamide. NAD can be formed from nicotinamide. They found that this prevented the decline of NAD -- and protected axons from disease. "We demonstrate that administering nicotinamide can … result in profound neuroprotection in [the mouse model of MS], providing a novel therapeutic possibility for MS patients," Kaneko and colleagues conclude. Of course, clinical trials will be needed to find out if vitamin B3 really can be a safe and effective treatment for multiple sclerosis. SOURCES: Kaneko, S. Journal of Neuroscience, Sept. 20, 2006; vol 26, manuscript received ahead of publication. News release, Children's Hospital, Boston. © 2006 WebMD Inc. All rights reserved. Right now I'm having amnesia and deja vu at the same time.. All-new Yahoo! Mail - Fire up a more powerful email and get things done faster. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 5, 2006 Report Share Posted October 5, 2006 It's a good thing I'm taking my B-50's! 50 mg per capsule and I take two a day. Okay, okay, so I've not been good about taking my supplements lately... except my morning SAMe! LOLOL But it's there, when I might remember to take it! Hey, I'll go dot hat right now. LOL Challis Sharon Marsden wrote: http://www.medicinenet.com/script/main/art.asp?articlekey=64251 Vitamin B3 May Help MS Mouse Study: Vitamin B3 Protects Brain Cells -- Even in Late-Stage Multiple Sclerosis By DeNoonWebMD Medical News Reviewed By Louise Chang, MDon Tuesday, September 19, 2006 Sept. 19, 2006 -- The newest treatment for multiple sclerosis might be vitamin B3 , mouse studies suggest. Nicotinamide is a form of vitamin B3 closely related to niacin. In a mouse model of MS, nicotinamide protects brain cells from degeneration. Given in the early stages of disease, it offered "dramatic protection." Given in late disease, it protected against further brain damage and new disease symptoms, report Shinjiro Kaneko, MD, and colleagues at Children's Hospital, Boston. Both effects would be welcomed by people with MS. Current MS treatments work only in the early "relapsing-remitting" phase of the disease. Nothing currently slows the devastating later "chronic progressive" stage of MS. "The earlier therapy was started, the better the effect, but we hope nicotinamide can help patients who are already in the chronic stage," Kaneko said, in a news release. "We hope that our work will initiate a clinical trial, and that nicotinamide could be used in real patients." Kaneko and colleagues report their findings in the Sept. 20 issue of the Journal of Neuroscience. Nerve Fiber Protection During multiple sclerosis, nerve fibers -- axons -- are damaged by self-destructive immune responses. It's possible, Kaneko and colleagues suggest, that protecting them from further damage could slow disease -- or even lead to some recovery. The researchers noticed that in the mouse model of MS, the axons of mice with hyperactive Wld genes aren't damaged as easily. The Wld gene, it turns out, makes an enzyme necessary for the production of another protein called NAD. Kaneko and colleagues found that as mice progress to MS disease, nerve levels of NAD decline. Kaneko and colleagues tried treating MS mice with nicotinamide. NAD can be formed from nicotinamide. They found that this prevented the decline of NAD -- and protected axons from disease. "We demonstrate that administering nicotinamide can … result in profound neuroprotection in [the mouse model of MS], providing a novel therapeutic possibility for MS patients," Kaneko and colleagues conclude. Of course, clinical trials will be needed to find out if vitamin B3 really can be a safe and effective treatment for multiple sclerosis. SOURCES: Kaneko, S. Journal of Neuroscience, Sept. 20, 2006; vol 26, manuscript received ahead of publication. News release, Children's Hospital, Boston. © 2006 WebMD Inc. All rights reserved. Right now I'm having amnesia and deja vu at the same time.. All-new Yahoo! Mail - Fire up a more powerful email and get things done faster. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 5, 2006 Report Share Posted October 5, 2006 I started them too. Thanks Challis. Trista Re: Vitamin B3 May Help MS It's a good thing I'm taking my B-50's! 50 mg per capsule and I take two a day. Okay, okay, so I've not been good about taking my supplements lately... except my morning SAMe! LOLOL But it's there, when I might remember to take it! Hey, I'll go dot hat right now. LOL Challis Sharon Marsden <wobbletowalk> wrote: http://www.medicinenet.com/script/main/art.asp?articlekey=64251 Vitamin B3 May Help MS Mouse Study: Vitamin B3 Protects Brain Cells -- Even in Late-Stage Multiple Sclerosis By DeNoonWebMD Medical News Reviewed By Louise Chang, MDon Tuesday, September 19, 2006 Sept. 19, 2006 -- The newest treatment for multiple sclerosis might be vitamin B3 , mouse studies suggest. Nicotinamide is a form of vitamin B3 closely related to niacin. In a mouse model of MS, nicotinamide protects brain cells from degeneration. Give! n in the early stages of disease, it offered "dramatic protection." Gi ven in late disease, it protected against further brain damage and new disease symptoms, report Shinjiro Kaneko, MD, and colleagues at Children's Hospital, Boston. Both effects would be welcomed by people with MS. Current MS treatments work only in the early "relapsing-remitting" phase of the disease. Nothing currently slows the devastating later "chronic progressive" stage of MS. "The earlier therapy was started, the better the effect, but we hope nicotinamide can help patients who are already in the chronic stage," Kaneko said, in a news release. "We hope that our work will initiate a clinical trial, and that nicotinamide could be used in real patients." Kaneko and colleagues report their findings in the Sept. 20 issue of the Journal of Neuroscience. Nerve Fiber Protection During multiple sclerosis, nerve fibers -- axons -- are damaged by self-destructive immune responses. It's possible, Kaneko and colleagues suggest, that protecting them from further damage could slow disease -- or even lead to some recovery. The researchers noticed that in the mouse model of MS, the axons of mice with hyperactive Wld genes aren't damaged as easily. The Wld gene, it turns out, makes an enzyme necessary for the production of another protein called NAD. Kaneko and colleagues found that as mice progress to MS disease, nerve levels of NAD decline. Kaneko and colleagues tried treating MS mice with nicotinamide. NAD can be formed from nicotinamide. They found that this prevented the decline of NAD -- and protected axons from disease. "We demonstrate that administering nicotinamide can … result in profound neuroprotection in [the mouse model of MS], providing a novel therapeutic possibility for MS patients," Kaneko and colleagues conclude. Of course, clinical trials will be needed to find out if vitamin B3 really can be a safe and effective treatment for multiple sclerosis. SOURCES: Kaneko, S. Journal of Neuroscience, Sept. 20, 2006; vol 26, manuscript received ahead of publication. News release, Children's Hospital, Boston. © 2006 WebMD Inc. All rights reserved. Right now I'm having amnesia and deja vu at the same time.. All-new Yahoo! Mail - Fire up a more powerful email and get things done faster. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 5, 2006 Report Share Posted October 5, 2006 I started them too. Thanks Challis. Trista Re: Vitamin B3 May Help MS It's a good thing I'm taking my B-50's! 50 mg per capsule and I take two a day. Okay, okay, so I've not been good about taking my supplements lately... except my morning SAMe! LOLOL But it's there, when I might remember to take it! Hey, I'll go dot hat right now. LOL Challis Sharon Marsden <wobbletowalk> wrote: http://www.medicinenet.com/script/main/art.asp?articlekey=64251 Vitamin B3 May Help MS Mouse Study: Vitamin B3 Protects Brain Cells -- Even in Late-Stage Multiple Sclerosis By DeNoonWebMD Medical News Reviewed By Louise Chang, MDon Tuesday, September 19, 2006 Sept. 19, 2006 -- The newest treatment for multiple sclerosis might be vitamin B3 , mouse studies suggest. Nicotinamide is a form of vitamin B3 closely related to niacin. In a mouse model of MS, nicotinamide protects brain cells from degeneration. Give! n in the early stages of disease, it offered "dramatic protection." Gi ven in late disease, it protected against further brain damage and new disease symptoms, report Shinjiro Kaneko, MD, and colleagues at Children's Hospital, Boston. Both effects would be welcomed by people with MS. Current MS treatments work only in the early "relapsing-remitting" phase of the disease. Nothing currently slows the devastating later "chronic progressive" stage of MS. "The earlier therapy was started, the better the effect, but we hope nicotinamide can help patients who are already in the chronic stage," Kaneko said, in a news release. "We hope that our work will initiate a clinical trial, and that nicotinamide could be used in real patients." Kaneko and colleagues report their findings in the Sept. 20 issue of the Journal of Neuroscience. Nerve Fiber Protection During multiple sclerosis, nerve fibers -- axons -- are damaged by self-destructive immune responses. It's possible, Kaneko and colleagues suggest, that protecting them from further damage could slow disease -- or even lead to some recovery. The researchers noticed that in the mouse model of MS, the axons of mice with hyperactive Wld genes aren't damaged as easily. The Wld gene, it turns out, makes an enzyme necessary for the production of another protein called NAD. Kaneko and colleagues found that as mice progress to MS disease, nerve levels of NAD decline. Kaneko and colleagues tried treating MS mice with nicotinamide. NAD can be formed from nicotinamide. They found that this prevented the decline of NAD -- and protected axons from disease. "We demonstrate that administering nicotinamide can … result in profound neuroprotection in [the mouse model of MS], providing a novel therapeutic possibility for MS patients," Kaneko and colleagues conclude. Of course, clinical trials will be needed to find out if vitamin B3 really can be a safe and effective treatment for multiple sclerosis. SOURCES: Kaneko, S. Journal of Neuroscience, Sept. 20, 2006; vol 26, manuscript received ahead of publication. News release, Children's Hospital, Boston. © 2006 WebMD Inc. All rights reserved. Right now I'm having amnesia and deja vu at the same time.. All-new Yahoo! Mail - Fire up a more powerful email and get things done faster. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 6, 2006 Report Share Posted October 6, 2006 The B-50s or the SAMe?? ) Challis Trista wrote: I started them too. Thanks Challis. Trista Re: Vitamin B3 May Help MS It's a good thing I'm taking my B-50's! 50 mg per capsule and I take two a day. Okay, okay, so I've not been good about taking my supplements lately... except my morning SAMe! LOLOL But it's there, when I might remember to take it! Hey, I'll go dot hat right now. LOL Challis Sharon Marsden <wobbletowalk> wrote: http://www.medicinenet.com/script/main/art.asp?articlekey=64251 Vitamin B3 May Help MS Mouse Study: Vitamin B3 Protects Brain Cells -- Even in Late-Stage Multiple Sclerosis By DeNoonWebMD Medical News Reviewed By Louise Chang, MDon Tuesday, September 19, 2006 Sept. 19, 2006 -- The newest treatment for multiple sclerosis might be vitamin B3 , mouse studies suggest. Nicotinamide is a form of vitamin B3 closely related to niacin. In a mouse model of MS, nicotinamide protects brain cells from degeneration. Give! n in the early stages of disease, it offered "dramatic protection." Gi ven in late disease, it protected against further brain damage and new disease symptoms, report Shinjiro Kaneko, MD, and colleagues at Children's Hospital, Boston. Both effects would be welcomed by people with MS. Current MS treatments work only in the early "relapsing-remitting" phase of the disease. Nothing currently slows the devastating later "chronic progressive" stage of MS. "The earlier therapy was started, the better the effect, but we hope nicotinamide can help patients who are already in the chronic stage," Kaneko said, in a news release. "We hope that our work will initiate a clinical trial, and that nicotinamide could be used in real patients." Kaneko and colleagues report their findings in the Sept. 20 issue of the Journal of Neuroscience. Nerve Fiber Protection During multiple sclerosis, nerve fibers -- axons -- are damaged by self-destructive immune responses. It's possible, Kaneko and colleagues suggest, that protecting them from further damage could slow disease -- or even lead to some recovery. The researchers noticed that in the mouse model of MS, the axons of mice with hyperactive Wld genes aren't damaged as easily. The Wld gene, it turns out, makes an enzyme necessary for the production of another protein called NAD. Kaneko and colleagues found that as mice progress to MS disease, nerve levels of NAD decline. Kaneko and colleagues tried treating MS mice with nicotinamide. NAD can be formed from nicotinamide. They found that this prevented the decline of NAD -- and protected axons from disease. "We demonstrate that administering nicotinamide can … result in profound neuroprotection in [the mouse model of MS], providing a novel therapeutic possibility for MS patients," Kaneko and colleagues conclude. Of course, clinical trials will be needed to find out if vitamin B3 really can be a safe and effective treatment for multiple sclerosis. SOURCES: Kaneko, S. Journal of Neuroscience, Sept. 20, 2006; vol 26, manuscript received ahead of publication. News release, Children's Hospital, Boston. © 2006 WebMD Inc. All rights reserved. Right now I'm having amnesia and deja vu at the same time.. All-new Yahoo! Mail - Fire up a more powerful email and get things done faster. Get your email and more, right on the new Yahoo.com Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 6, 2006 Report Share Posted October 6, 2006 B-50. T. Re: Vitamin B3 May Help MS It's a good thing I'm taking my B-50's! 50 mg per capsule and I take two a day. Okay, okay, so I've not been good about taking my supplements lately... except my morning SAMe! LOLOL But it's there, when I might remember to take it! Hey, I'll go dot hat right now. LOL Challis Sharon Marsden <wobbletowalk> wrote: http://www.medicinenet.com/script/main/art.asp?articlekey=64251 Vitamin B3 May Help MS Mouse Study: Vitamin B3 Protects Brain Cells -- Even in Late-Stage Multiple Sclerosis By DeNoonWebMD Medical News Reviewed By Louise Chang, MDon Tuesday, September 19, 2006 Sept. 19, 2006 -- The newest treatment for multiple sclerosis might be vitamin B3 , mouse studies suggest. Nicotinamide is a form of vitamin B3 closely related to niacin. In a mouse model of MS, nicotinamide protects brain cells from degeneration. Give! n in the early stages of disease, it offered "dramatic protection." Gi ven in late disease, it protected against further brain damage and new disease symptoms, report Shinjiro Kaneko, MD, and colleagues at Children's Hospital, Boston. Both effects would be welcomed by people with MS. Current MS treatments work only in the early "relapsing-remitting" phase of the disease. Nothing currently slows the devastating later "chronic progressive" stage of MS. "The earlier therapy was started, the better the effect, but we hope nicotinamide can help patients who are already in the chronic stage," Kaneko said, in a news release. "We hope that our work will initiate a clinical trial, and that nicotinamide could be used in real patients." Kaneko and colleagues report their findings in the Sept. 20 issue of the Journal of Neuroscience. Nerve Fiber Protection During multiple sclerosis, nerve fibers -- axons -- are damaged by self-destructive immune responses. It's possible, Kaneko and colleagues suggest, that protecting them from further damage could slow disease -- or even lead to some recovery. The researchers noticed that in the mouse model of MS, the axons of mice with hyperactive Wld genes aren't damaged as easily. The Wld gene, it turns out, makes an enzyme necessary for the production of another protein called NAD. Kaneko and colleagues found that as mice progress to MS disease, nerve levels of NAD decline. Kaneko and colleagues tried treating MS mice with nicotinamide. NAD can be formed from nicotinamide. They found that this prevented the decline of NAD -- and protected axons from disease. "We demonstrate that administering nicotinamide can … result in profound neuroprotection in [the mouse model of MS], providing a novel therapeutic possibility for MS patients," Kaneko and colleagues conclude. Of course, clinical trials will be needed to find out if vitamin B3 really can be a safe and effective treatment for multiple sclerosis. SOURCES: Kaneko, S. Journal of Neuroscience, Sept. 20, 2006; vol 26, manuscript received ahead of publication. News release, Children's Hospital, Boston. © 2006 WebMD Inc. All rights reserved. Right now I'm having amnesia and deja vu at the same time.. All-new Yahoo! Mail - Fire up a more powerful email and get things done faster. Get your email and more, right on the new Yahoo.com Quote Link to comment Share on other sites More sharing options...
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