chicken soup

[Guest guest]

Like Boric Acid, estrace is not chicken soup. Note 4th last line

There is a concern here of local vulvar cancer and local estrogen therapy

Also, not mentioned is the impact of systmeic absorption. Could it be absorbed

systemically producing other effects such as stimulating an estrogen sensive

beasr cancer or producing a stroke?

No evidence of the latter 2 but likely not well tested.

Of cours eit could be that the topical agents were used to treat a condition

that became cancerhe

When cortisone first came out in the early 50's it was the miracle drugm, used

for everything.

Then people beganto realize there were serious sude effects

Analyzing prior clinical events at presentation in 102 women with vulvar

carcinoma. Evidence of diagnostic delays.

RW, Joura EA

Department of Gynaecologic Oncology, National Women's Hospital, Auckland, New

Zealand.

OBJECTIVE: To evaluate the clinical events preceding the diagnosis of squamous

cell carcinoma of the vulva. STUDY DESIGN: One hundred two women presenting with

squamous cell carcinoma of the vulva to a gynecologic oncology unit between 1989

and 1996 were prospectively evaluated by a single investigator. History,

clinical findings, previous physician contact, investigations and treatment were

analyzed. RESULTS: Vulvar symptoms were present for more than six months in 88%

and for more than five years in 28% of women. Eighty-five percent of patients

had clinical evidence of abnormal skin adjacent to the cancer. Thirty-one

percent of women had three or more medical consultations for vulvar symptoms

prior to the diagnosis of cancer. Twenty-five percent of women had had a

previous diagnostic vulvar biopsy, and 27% gave a history of having applied

topical estrogen or corticosteroid to the vulva. Patients with a history of a

preceding biopsy were more likely to present with stage 1 disease. CONCLUSION:

Avoidable factors appear to be present in many women who present with vulvar

cancer. A more active approach to the diagnosis and management of precursor

lesions may often prevent the development of vulvar cancer.

PMID: 10509298, UI: 99438714