Guest guest Posted July 8, 2002 Report Share Posted July 8, 2002 Bebe, Others may know more about the glutamate. I'll let them tell you. On the reading side: THE DIVINE SECRETS OF THE YA-YA SISTERHOOD, is good. On an uplifting note, The Road Less Traveled by M. Peck, Unconditional Life and Ageless Body Timeless Mind by Deepak Chopra are interesting. Grisham's books, all of them, are entertaining with a little excitement thrown in. He writes mostly about lawyers, since he is one, and has some good plots. Just go to a bookstore and look around. I can't, because I see too many things I want. But it does give me an idea about what to look for in the library. Mike Gray At 08:42 AM 7/8/02 -0400, you wrote: >HI: >Much of my " Laymen's Research " mentions Glutomate and the abnormal glutamate >metabolism that occurs. >Hopefully some of you more knowledgeable people might educate me as to >whether there are certain foods to avoid/eat or vitamins to take to >decrease/increase this abnormal glutamate metabolism. >I feel very powerless and want to take some sort of action...I've volunteered >for any and all research that will use a non-diagnosed PLS/SLOW PROGRESSING >ALS person. >Anyone out there read any good, distracting books that they would like to >recommend >Bebe > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 23, 2008 Report Share Posted July 23, 2008 Dear Beverly, Article form Life extension: Research shows that theanine has numerous health-enhancing effects, including protecting cognitive function. In studies of neurons in cell culture, theanine significantly reversed glutamate-induced toxicity, a major cause of degenerative brain decline. Based on published data Wish you the best. I use theaninne and Vitalzym for my depression...Lydia > > Hi guys. I've been doing more research on the glutamate toxicity Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 23, 2008 Report Share Posted July 23, 2008 Hi Bev, I believe Bernie pointed out recently that LDN also acts as a glutamate blocker. For more information about LDN visit http://tinyurl.com/2boot2 Sincerely, Dudley Delany http://profiles.yahoo.com/dudley_delany Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 23, 2008 Report Share Posted July 23, 2008 Dear Beverly, Sorry this is so long Ive been trying to chop off the other postings. Anyway, I really feel for you with the depression. I also started the long road to ms with depression. With me it began almost immediately after I contracted pneumonia when I was 40. I was in hospital with the psychiatrist trying a number of drugs to help. They didn't until he tried MAOI (an old antidressant) which worked very well until he tried to take me off them 8 months later. The depression returned and so I was kept on them for about six years. I came off them by cutting them down very, very slowly eventually succeeding but was put on Effexor which helped but my liver function tests after about a year were not good so I was taken off, given an SSRI antidepressant plus amitriptyline _ this was because the psycho and the neruro had different ideas as to which was the best and I ended up on both. Actually, my depression symptoms were successfully treated and a got a good night's sleep. Now about three years after the depression appeared I developed optic neuritis and, like you, was diagnosed with ms. Fast foward another six years. I was on the BBD _ no dramatic improvement but I was in good health overall. I then began to learn of LDN and thought that was a good thing to try. As I have said before on this site, I contacted Dr Bob Lawrence who supplied the LDN and also spoke at length about nuitritional treatment for depression. He was incredibly helpful and I read his papers on the link between ms depression and zinc deficiency. I had a chat with him this afternoon when I rang up to order some more LDN. The conversation among other things was about low zinc levels which are amazingly common in people with ms and depression. For your information I really think that it may be worth you starting to take 25mgs of zinc once a day for a week and then increase this to 50mgs a week or so later. You cam slowly increase this _ certainly to a 100mgs a day (in split doseses). Dr Lawrence uses a zinc taste test to find out whether there is enough zinc in an individual. He supplies a small bottle of zinc sulphate which you keep in the fridge. Take it out for a couple of hours and then try a small tasting. If after 10 seconds the liquig is tasteless or very bland it shows a deficiency in zinc. An immediate strong unpleasant metallic taste indicates you have sufficient zinc. It is important to take at different time of the day a small supplement _ 2mgs of copper. You do not have to increase the copper amount even though you have increased the zinc. In addition to the zinc it is important to take a lot of omega 3 supplements _ preferably six grammes a day (flaxseed oil or fish omega3 is fine. Make sure you have taken a good vitamin B50 complex. The other mineral that is need is vanadium and a daily tablet of vandyl sulphate is important. Each nutrient should be itroduced one at a time in order to deduce the relevant butrient that is deficient. Since I have been taking those supplements there has been a definite improvement in the onset of any depression wobbles. I ditched the SSRI last October and had lowered slowly the amitriptyline to 70 mgs. I am strill trying to get this lower. I really, really, hope you find some relief by possibly trying this. I am a total cynic about everything but this really seems to have helped. Depression is horrible. There is a link with ms. This could be pathological or reactive to being in a horrible situation. I was like you depressed and then diagnosed with ms. The depression has gone the ms hasn't bt I am working on it. Love Judith Glutamate Hi guys. I've been doing more research on the glutamate toxicity in MS. Found something interesting; thought I'd pass it along. Someone suggested to me that my long-standing (3 1/2 yrs) treatment-resistant depression might be connected to the MS. I knew MS could cause depression, but I never thought they might be connected. Started looking and lo and behold, found a reference to depression related to glutamate toxicity, just like MS. Like maybe the depression was the first symptom of my MS, starting 3 yrs before physical symptoms. The scary part for me is that if I think my depression might be as incurable as the MS, I don't think I could bear up. With good mental health, anything is possible. With bad mental health, nothing happens. I guess I just have to believe that all the stuff I am doing for the MS will eventually help the depression. What took 50 yrs to develop isn't going to be corrected in a few months, huh? Anyway, thought I'd pass this along in case anyone else is suffering from depression---there is a list of glutamate blockers at the end of info.: B3, COQ10, herbs, magnesium, vit E succinate, and I am now taking L-Pyroglutamic Acid, which is supposed to block glutamate. And all these would obviously be good for MS as well. THANKS FOR BEING A PLACE I CAN LEARN, SHARE AND VENT! It means so much to me!! Beverly " DOPAMINE-GLUTAMATE RELATIONSHIP: Glutamate is an excitatory amino acid neurotransmitter that is cytotoxic when over-expressed at synaptic terminals. As a result, elevated glutamate appears to play a role in several diseases, including ischemia and methamphetamine-induced toxicity. Berman and Hastings52 have shown the reactive oxygen species and dopamine oxidation products can modify glutamate transport function, resulting in the elevated levels implicated in such neuro-degeneration. It follows, therefore, that if the three neurologic diseases under discussion (MS, ALS and Parkinson's) involve the excessive oxidation of dopamine, abnormally high levels of cytotoxic glutamate will also be present in patients suffering from them. Glutamate abnormalities have been found also in multiple sclerosis where elevated levels are related to relapses. Increases in serum glutamate do not occur sharply during relapses, rather they rise gradually for a month or two prior to the onset of a clinical relapse, peak during it and then slowly decline.55 Barkhatova and coworkers also have established elevated glutamate levels in the cerebral fluid of patients with multiple sclerosis.56 ********************************************************************** **Conclusions. Long-term iodine deficiency appears linked to abnormalities in the dopaminergic system that include an increased number of dopamine receptors. It is argued that this raises susceptibility to dopamine oxidation which, in turn, causes deficiencies of the antioxidant enzymes Cu/Zn superoxide dismutase, glutathione peroxidase and catalase. Dopamine deficiency also leads to elevated cytotoxic glutamate levels. Implications of the iodine- dopachrome-glutamate hypothesis, for treatment of these three neurologic disorders, are then discussed. Possible interventions include the use of levodopa, vitamin B3, Coenzyme Q10, various antioxidants, amino acids, iodine and glutamate antagonists. *************************************************** However, excess glutamate can cause neurons to die from excitotoxicity. Excitotoxicity is the phenomenon of spreading neuron death that occurs in response to a specific brain injury. Most studies of this focus on the role of glutamate in stroke. High levels of glutamate and excitatory neurotransmitter activity can also cause cause brain cells to die without there being a specific brain injury. ****************************************************** Recent studies examining the role of glutamate in DEPRESSION have found that glutamate antagonists can reduce depressive symptoms. This suggests that a new target for antidepressant therapies and that a combined monoamine/glutamate approach may provide relief for a broader range of patients with treatment resistant depression. Studies examining patients with major depressive disorders have also found a higher ratio of excitatory to inhibitory amino acids. Anxiety models have successfully used glutamate antagonists suggesting a similar excitatory:inhibitory neurotransmitter imbalance in these patients. Research in this area continues. ********************************************************** There are a lot of things that act as glutamate receptor blockers. You know, like silymarin, curcumin and ginkgo biloba. These things are known to directly block glutamate receptors and reduce excitotoxicity. Curcumin is very potent. Most of your flavonoids reduce excitotoxicity. Magnesium is particularly important, because magnesium can block the NMDA glutamate type receptor. That's its natural function, so it significantly reduces toxicity. Vitamin E succinate is powerful at inhibiting excitotoxicity. " Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 23, 2008 Report Share Posted July 23, 2008 *I eat a lot of seaweed for the iodine and interestingly, it also contains natural glutamates (so do fermented vegetables and I eat those too and drink fermented kombucha tea). This information may pertain to the manipilated glutamates, msg. That is potent stuff that wipes me out. I no longer eat any processed foods because of the msg and other preservatives they contain, not to mention that they're dead food. ********************************************************************* > **Conclusions. Long-term iodine deficiency appears linked to > abnormalities in the dopaminergic system that include an increased > number of dopamine receptors. It is argued that this raises > susceptibility to dopamine oxidation which, in turn, causes > deficiencies of the antioxidant enzymes Cu/Zn superoxide dismutase, > glutathione peroxidase and catalase. Dopamine deficiency also leads > to elevated cytotoxic glutamate levels. Implications of the iodine- > dopachrome-glutamate hypothesis, for treatment of these three > neurologic disorders, are then discussed. Possible interventions > include the use of levodopa, vitamin B3, Coenzyme Q10, various > antioxidants, amino acids, iodine and glutamate antagonists. > *************************************************** Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 23, 2008 Report Share Posted July 23, 2008 Thanks Dudley--I am on LDN since March. Beverly > > Hi Bev, > > I believe Bernie pointed out recently that LDN also acts as a glutamate blocker. > > For more information about LDN visit > > http://tinyurl.com/2boot2 > > Sincerely, > > Dudley Delany > > http://profiles.yahoo.com/dudley_delany > Quote Link to comment Share on other sites More sharing options...
Recommended Posts
Join the conversation
You are posting as a guest. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.