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Amiodarone

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In a message dated 8/12/2002 10:02:51 PM Central Daylight Time,

yainel@... writes:

> Guy,

> I'm on amiodarone also, but I'm having trouble with my eyes being

> sensitive to the sun, and also go tired really fast. I hate this. How

> do the check your lungs? I've only been on it for about 6 weeks. I go

> for a blood test Wednesday. Don't you have your thyriod checked and

> did you have any problems like I'm having? thanks....Nel

>

>

Hi Nel

The doctors should have done baseline tests before ever starting you on

amiodarone. They gave me a pulmonary test which tested my lungs for

flexibility and capacity, they also gave me a blood test which included a

baseline test for thyroid activity. I did not have an eye test since I was at

the eye Dr for my normal check-up a few months earlier. I have had no eye

sensitivity to sunlight. The nurse at the Cardio office said to not worry

about the thyroid because they will just give me synthroid which is an

artificial replacement. I was not impressed with her response because I don't

want to be dependent on any more drugs. I have not been tired due to the

amiodarone but I seem to be lucky in that respect, I take attenalol also with

no noticeable effects although early on when I just started I had some pretty

bad dizzy spells when I got up in the morning, hopefully your tiredness will

go away. I was started on 400mg daily for a month and then changed to 200mg.

Simultaneously with the cutback to 200mg I had pretty severe stomach problems

that went away in about 4 days and I don't know if I had a bug or if it was

the heavier dose of amiodarone.

Good Luck( to both of us)

Guy

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  • 3 months later...

In a message dated 12/16/2002 10:31:57 AM Central Standard Time,

sferm@... writes:

> Does anybody happen to know how long it takes your body to be free of

> Amiodarone once you have stopped taking it ?

>

> Steve

>

As I recall it is in the range of 3 to 6 mos.

Guy

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<Does anybody happen to know how long it takes your body to be free of

Amiodarone once you have stopped taking it ?>

" Amiodarone and N-desethyl-amiodarone [the pharmacologically active

metabolite] are virtually exclusively eliminated hepatically, although

biliary excretion may play a small role in the excretion of amiodarone. As a

consequence of its distribution characteristics, the elimination of

amiodarone occurs in a biphasic fashion, with an initial reduction of plasma

concentrations of 50% occurring within 10 days. The terminal elimination

half-life ranges from 26-107 days with a mean of around 53 days. "

I think, amongst other things, it will depend on how long you've been taking

it and how large you are.

You can certainly be looking at many months.

--

D

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<Does anybody happen to know how long it takes your body to be free of

Amiodarone once you have stopped taking it ?>

" Amiodarone and N-desethyl-amiodarone [the pharmacologically active

metabolite] are virtually exclusively eliminated hepatically, although

biliary excretion may play a small role in the excretion of amiodarone. As a

consequence of its distribution characteristics, the elimination of

amiodarone occurs in a biphasic fashion, with an initial reduction of plasma

concentrations of 50% occurring within 10 days. The terminal elimination

half-life ranges from 26-107 days with a mean of around 53 days. "

I think, amongst other things, it will depend on how long you've been taking

it and how large you are.

You can certainly be looking at many months.

--

D

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