s translation/ article on VVS inflammation

[Guest guest]

HI

I know I already commended you on sending the site, but really wanted to

congratulate and thank you AGAIN for condensing it down to simple language.

You did a beautiful job. The KISS theory... *chuckle* I know when I first

read your introduction, I thought you were an 'Engineer' so very precise, I

loved it. I definitely don't have that knack.. *chuckle*.

(go to the archives ladys and check out the article)...by the way, I

couldn't pull it up with your link, but just went to egroups, then found our

group and went in that way. (maybe because we need to sign in first eh? )

Just a few more comments re: the article.

I was glad to see there was a very low correlation with HPV, in fact it had

the lowest % rate and yet the highest with VV. Also that it points out

that it is 'rare' to have 2 copies of the Allele2 for IL-1 RA. 'My'

thoughts would be in that case it's more likely that women with that Allele

would just feel the pain more severely and not necessarily a possible link

or cause for VV, because WOW do we feel the pain. *sigh*.. Just musing out

loud here.

Thanks again J. Warmest Dee~

[Guest guest]

> that it points out that it is 'rare' to have 2 copies of the

> Allele2 for IL-1 RA. 'My' thoughts would be in that case it's

> more likely that women with that Allele would just feel the pain

> more severely and not necessarily a possible link or cause for VV,

> because WOW do we feel the pain. *sigh*.. Just musing out

> loud here.

Hi Dee,

Yes, it does seem that the " 2 " gene is not a direct cause of VV.

It's true that 50% of the women with VV had that rare gene

combination, but that also means that 50% didn't. And there are

normal women who have those genes and no VV. And they say towards

the end that a similar pattern of genetics is found in others with

inflammatory diseases. So to me that says that these genes don't

cause VV directly. But it does say that having that combination

makes a person more likely to get an inflammatory disease, which is

what vulvar vestibulitis is for many people. Since those with that

combination are less able to end inflammation, it is more likely to

become chronic. So while it doesn't explain how the darn problem

starts, it can perhaps explain in *some* women why it continues,

which may help with treatments someday.

jessica

[Guest guest]

> that it points out that it is 'rare' to have 2 copies of the

> Allele2 for IL-1 RA. 'My' thoughts would be in that case it's

> more likely that women with that Allele would just feel the pain

> more severely and not necessarily a possible link or cause for VV,

> because WOW do we feel the pain. *sigh*.. Just musing out

> loud here.

Hi Dee,

Yes, it does seem that the " 2 " gene is not a direct cause of VV.

It's true that 50% of the women with VV had that rare gene

combination, but that also means that 50% didn't. And there are

normal women who have those genes and no VV. And they say towards

the end that a similar pattern of genetics is found in others with

inflammatory diseases. So to me that says that these genes don't

cause VV directly. But it does say that having that combination

makes a person more likely to get an inflammatory disease, which is

what vulvar vestibulitis is for many people. Since those with that

combination are less able to end inflammation, it is more likely to

become chronic. So while it doesn't explain how the darn problem

starts, it can perhaps explain in *some* women why it continues,

which may help with treatments someday.

jessica