Vitamin D and All-Cause Mortality in the General Population

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Vitamin D and All-Cause Mortality in the General Population

http://www.vitasearch.com/CP/weeklyupdates/

Reference: " 25-hydroxyvitamin D levels and the risk of mortality in the

general population, " Melamed ML, Michos ED, et al, Arch Intern Med,

2008; 168(15): 1629-37. (Address: Division of Nephrology, Department of

Medicine, Albert Einstein College of Medicine, 1300 Park Ave,

Ullmann 615, Bronx, NY 10461, USA. E-mail: mmelamed@... ).

Summary: In a study involving 13,331 nationally representative adults

20 years of age or older who were followed up with for a median 8.7

years, a 26% increased rate of all-cause mortality was found among

subjects in the lowest quartile of vitamin D status (25(OH)D < 17.8

ng/mL) - with a mortality rate ratio of 1.26 and a population

attributable risk of 3.1%. In addition, increasing age, female sex,

nonwhite race/ethnicity, diabetes, current smoking, and higher BMI were

all independently associated with a higher odds of having vitamin D

deficiency (being in the lowest quartile), while greater physical

activity, vitamin D supplementation, and non-winter season were

inversely associated with vitamin D deficiency. These results suggest

that vitamin D deficiency may be, " independently associated with

all-cause mortality in the general population. "

--

ne Holden, MS, RD

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