Vitamin D3 Supplementation May Benefit Patients with Cutaneous Lupus Erythematosus

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Vitamin D3 Supplementation May Benefit Patients with Cutaneous Lupus

Erythematosus

http://www.vitasearch.com/CP/weeklyupdates/

Reference: " Photoprotective behaviour and sunscreen use: impact on

vitamin D levels in cutaneous lupus erythematosus, " Cusack C, Danby C,

et al, Photodermatol Photoimmunol Photomed, 2008; 24(5): 260-7.

(Address: Dr. Gillian , Department of Dermatology, Beaumont

Hospital, Dublin, Ireland. E-mail: gillianmmurphy@... ).

Summary: In a study involving 52 patients with cutaneous lupus

erythematosus (CLE), suboptimal vitamin D status was found to be

prevalent, particularly among those who restricted their exposure to the

sun or used sunscreen regularly and did not take vitamin D supplements.

Restricting sun exposure is a common practice among patients with CLE.

Of the 52 patients, 65% were found to have 25(OH)D levels < 75 nmol/l

and 3.8% of patients were found to have significantly low values (<25

nmol/l). Those who avoided the sun or used sunscreen daily had

significantly lower values of 25(OH)D, while those who supplemented

daily with vitamin D3 (cholecalciferol) were found to have significantly

higher values. Subjects with renal disease had low levels of 25(OH)D,

regardless of vitamin D3 supplementation. The authors conclude, " We

suggest that patients with cutaneous lupus erythematous have suboptimal

25(OH)D levels, which are significantly raised by the addition of at

least 400 IU/day of cholecalciferol. We recommend supplementation with

an active vitamin D analogue in collaboration with a consultant

nephrologist, for the subgroup of patients with renal disease. "

--

ne Holden, MS, RD

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