Use of Antibacterial Mouthwash May Attenuate Increase in Plasma Nitrite after Dietary Intake of Nitrate

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Use of Antibacterial Mouthwash May Attenuate Increase in Plasma Nitrite

after Dietary Intake of Nitrate

http://www.vitasearch.com/CP/weeklyupdates/

Reference: " The increase in plasma nitrite after a dietary nitrate load

is markedly attenuated by an antibacterial mouthwash, " Govoni M,

Lundberg JO, et al, Nitric Oxide, Aug 2008; [Epub ahead of print].

(Address: Department of Physiology and Pharmacology, Karolinska

Institutet, Nanna Svartz väg 2, S-171 77 Stockholm, Sweden).

Summary: In a crossover study involving 7 healthy volunteers, results

indicate that oral bacteria may play a significant role in the increase

in saliva and plasma nitrite after a dietary nitrate load (dietary

inorganic nitrate is abundant in vegetables); therefore, the use of an

antibacterial mouthwash may attenuate this increase. The participants

were assigned to rinse their mouths with or without a commercially

available chlorhexidine-containing antibacterial mouthwash prior to oral

intake of sodium nitrate (100 mg/kg dissolved in water). Saliva and

plasma levels of nitrate and nitrite (nitrate may be metabolized in vivo

to form nitrite and then bioactive nitric oxide) increased greatly after

the nitrate load in the control group. However, rinsing with the

antibacterial mouthwash prior to nitrate load was associated with a

significant reduction in saliva and plasma levels of nitrite. Thus, the

authors of this study conclude, " …the acute increase in plasma nitrite

seen after a nitrate load is critically dependent on nitrate reduction

in the oral cavity by commensal bacteria. The removal of these bacteria

with an antibacterial mouthwash will very likely attenuate the

NO-dependent biological effects of dietary nitrate. "

--

ne Holden, MS, RD

" Ask the Parkinson Dietitian " http://www.parkinson.org/

" Eat well, stay well with Parkinson's disease "

" Parkinson's disease: Guidelines for Medical Nutrition Therapy "

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