Reduced Selenium Status May Increase the Risk of the Metabolic Syndrome

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Reduced Selenium Status May Increase the Risk of the Metabolic Syndrome

http://www.vitasearch.com/CP/weeklyupdates/

Reference: " Selenium intake reduces serum C3, an early marker of

metabolic syndrome manifestations, in healthy young adults, " Puchau B,

Zulet MA, et al, Eur J Clin Nutr, 2008 Nov 5; [Epub ahead of print].

(Address: Dr JA Martínez, Department of Nutrition and Food Sciences,

Physiology and Toxicology, University of Navarra, Calle Irunlarrea 1,

31008 Pamplona, Spain. E-mail: jalfmtz@... ).

Summary: In a study involving 100 healthy young adults between the ages

of 18 and 34 years, selenium status was found to be associated with

levels of serum complement factor 3 (C3), a marker of increased risk for

the metabolic syndrome. Levels of serum C3 were associated with

tricipital skinfold thickness, sum of skinfold thicknesses, BMI, body

fat mass, waist-to-height ratio, serum glucose, serum triglycerides, and

nail selenium. Circulating levels of serum C3 were found to be

positively associated with several adiposity markers such as BMI, waist

circumference, waist-to-height ratio, body fat mass, and serum glucose

and triglycerides, while nail selenium levels were found to be

negatively associated with serum C3 concentrations. The authors

conclude, " These findings suggest a possible role for selenium intake in

the modulation of C3, whose assessment may be an early marker of

metabolic syndrome manifestations. "

--

ne Holden, MS, RD

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