Plasma Coenzyme Q10 May be a Predictor of Chronic Heart Failure Mortality

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Plasma Coenzyme Q10 May be a Predictor of Chronic Heart Failure Mortality

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Reference: " Coenzyme Q(10) An Independent Predictor of Mortality in

Chronic Heart Failure, " Molyneux SL, Florkowski CM, et al, J Am Coll

Cardiol, 2008; 52(18): 1435-1441. (Address: Dr. M.

Florkowski, Clinical Biochemistry Unit, Canterbury Health Laboratories,

P.O. Box 151, Christchurch 8140, New Zealand. E-mail:

chris.flrkowski@... ).

Summary: In a study involving 236 patients with chronic heart failure

(median age: 77 years), plasma coenzyme Q10 was found to be an

independent predictor of mortality (HR=2.0). Patients were followed up

with for a median 2.7 years. Median coenzyme Q10 concentration was found

to be 0.68 mumol/l, and the optimal coenzyme Q10 concentration for

prediction of mortality was found to be 0.73 mumol/l. The authors

conclude, " Our findings in a clearly defined, prospectively studied

group that CoQ10 depletion is associated with worse outcomes in CHF give

further support to the rationale of the intervention studies that have

already been initiated. "

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