Acetyl-L-Carnitine in the Treatment of Diabetic Peripheral Neuropathy

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Acetyl-L-Carnitine in the Treatment of Diabetic Peripheral Neuropathy

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Reference: " Role of acetyl-L-carnitine in the treatment of diabetic

peripheral neuropathy, " JD, s TF, et al, Ann Pharmacother,

2008; 42(11): 1686-91. (Address: Department of Clinical and

Administrative Sciences, College of Pharmacy, University of Louisiana at

Monroe, Monroe, LA, USA. E-mail: jevans@... ).

Summary: In this review of clinical trials, meta-analyses, and reviews

examining the role of acetyl-L-carnitine (ALC) in the treatment of

diabetic peripheral neuropathy, subjects who received at least 2 g/d ALC

were found to have reductions in pain, according to 2 clinical trials

involving 1,679 subjects. In one study, improvements in

electrophysiological factors such as nerve conduction velocities, was

found. Neuropathic pain was found to be reduced as well. In one trial,

nerve regeneration was found. ALC was found to be well tolerated. The

authors conclude, " Data on treatment of diabetic peripheral neuropathy

with ALC support its use. It should be recommended to patients early in

the disease process to provide maximal benefit. Further studies should

be conducted to determine the effectiveness of ALC in the treatment and

prevention of the worsening symptoms of DPN. "

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ne Holden, MS, RD

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