Latest GMO Research: Decreased Fertility, Immunological Alterations and Allergies

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Latest GMO Research: Decreased Fertility, Immunological Alterations and

Allergies

Dr. Damato, Ph.D.

http://www.NaturalNews.com/025001.html

(NaturalNews) Genetically modified organisms (GMOs) are created through

an inexact science of shooting genes spliced from bacteria, viruses,

insects, animals or humans with a .22 caliber pistol into the DNA of

plants or animals laced with a metal such as tungsten. This unsafe

science ostensibly supplants millions of years of evolution with little

or no scientific justification. In fact, recent research on GMO crops

have reported yields to be between 4 to 20 percent less than

conventional crops [1-6].

In the 1970's when genetic engineered was pioneered, scientists believed

the genome was static and genes could be altered in a uniform manner

with the organism only expressing the one intended modification. As

research progressed in the 1980's, scientists scrapped the idea of the

static genome and moved towards a dynamic genomic belief model. This

came about from the realization that by inserting a new gene into a

plant, a cascade of unintended consequences arose. Scientists found that

there was no possible way to introduce a new gene into an organism and

only get one intended result. The genes quickly changed based on a

myriad of unknown circumstances that sometimes could not be repeated in

the lab even though the exact same procedures were used. The levels of

instability from these newly created organisms were overwhelming, but

many scientists were silenced.

Safety has always been the number one priority of consumers when it

comes to GMOs; antithetically, the seed companies' only priority has

been to increase profits at any expense. Therefore, it is no surprise

that objective and unbiased researchers have recently added to the

growing knowledge of the realities of the increased instability and

unintended consequences regarding the long-term safety of GMOs. These

researchers recently found clear links among the consumption of GM-corn

and decreased fertility, immunological alterations in the gut and the

exacerbation and creation of allergies.

Fertility in GM-Fed Mice

Scientists in Austria recently conducted the first ever long-term

multi-generational feeding study of Monsanto's genetically modified (GM)

corn (NK 603 x MON 810) in mice [7]. The study consisted of two groups:

an experimental group, which was fed a 33% GM corn (maize) feed, and a

control group, which was fed an equivalent non-GM corn feed. The mice

were allowed to live a natural life and were monitored for four

generations. Scientists recorded organ weight, gene expression, body

mass, metabolism, life span and number of offspring of both groups of

mice. The scientists found that mice fed GM corn had significantly less

pups per litter than the control group on the third and fourth

generation. Furthermore, pups whose parents were fed GM-feed weighed

less at birth and at weaning and experienced significantly higher

mortality rates than those fed non-GM corn. Lead author of the study

Professor Zentek reported that there was a direct link between the

decrease in fertility and the GM diet and mice fed non-GM corn

reproduced more efficiently.

Gene Expression in GM-Fed Mice

Using a microarray analysis, the scientists reported that 1016 genes had

been differentially expressed in the mice fed GM corn with most being

up-regulated. Essentially, the GM-fed mice had hundreds of their

proteins, which are encoded by genes, expressed in an increased or

decreased quantity, which as a corollary altered certain biological

processes in their bodies. For example, sensory perception, ion

transport and the ability to breakdown proteins (proteolysis) were

down-regulated or under-expressed, while the ability of the mice to

regulate T-cells (a primary immunological response especially in

fighting cancer), circadian rhythm regulation and the FAS signalling

pathway (which is a major pathway for cell apoptosis and is important in

the elimination of cancers) were over-expressed. This study elucidates

the fact that biologic damage from GMOs may not manifest until the third

generation and details strong evidence for the mandatory labelling, and

even more so for the mass extinction, of these highly dangerous and

unnecessary foods.

Immunological Reactions in GM Fed Mice

Italian researchers at the National Institute of Nutrition in Rome,

Italy, recently published a study examining the effects of a 50 percent

GM-corn (maize) diet on the intestinal immune response of mice [8]. The

GM-corn was known as Monsanto's transgenic MON810 and was created using

an inserted foreign DNA sequence from the bacteria, Bacillus

thuringiensis (BT) designed to protect against a fungus known as the

Fusarium species. The study was conducted over 30 and 90-day periods

respectively, with mice from two groups, weaning age (mean of 21 days)

and old age (mean of 15 months). The study evaluated the peripheral and

intestinal immune response to long-term GM-corn and non-GM corn

consumption of each group across the two periods. The young and old mice

were used because of the lack of research on these subsets as well as

their potential susceptibility to immunological changes, more so than

non-aged adult animals.

The results of the long-term study revealed significant changes in the

immunophenotype of the gut, spleen, circulating lymphocytes and the

level of serum cytokines of the mice fed GM-corn. Immunophenotyping

essentially determines the expression of proteins by the cells. Any

differences in the expression of proteins between the control and the

experimental groups would be attributable to the GM diet. Specifically,

the researchers found an increased presence of several cytokines in the

GM fed mice, which are specifically involved in inflammatory and

allergic responses by the body. The researchers also found an increase

in the protein expression of lymphocytes (TCRγδ+ population). Within

this population, the γδT cells reside in the gut and are associated with

regulatory elements of the immune response, specific to infectious

agents [9-11]. Elevated amounts γδT cells have been found in asthmatics,

children suffering from food allergies, gastrointestinal symptoms and

juvenile arthritis [12]. The GM-fed mice also exhibited significant

alterations in the number of T and B cells, indicating a significantly

abnormal immune response to the genetically altered feed. Furthermore,

other researchers have found a newly expressed protein from the

consumption of GM corn (50 kDa γ-zein), which is a widely known

allergenic protein [13]. In conclusion, from the newly presented

research it is apparent that ingesting genetically engineered BT corn

not only invokes an anaphylaxis (allergenic) response within the body,

it also deregulates several proteins, inhibits fertility and alters the

overall immunological response by the body. Clearly, Monsanto whose sole

goal is to control the world through food, has a lot of explaining to do.

References

1. Benbrook, C.M. (1999). Evidence of the magnitude and consequences of

the Roundup Ready soybean yield drag from university-based varietal

trials in 1998. Ag BioTech InfoNet Technical Paper Number 1,

www.biotech-info.net/RR_yield_drag_98.pdf

2. University of Nebraska (2000). 'Research shows Roundup Ready soybeans

yield less', IANR News Service, www.biotechinfo.net/Roundup_soybeans_yi...

3. Griffiths, M. (1999). 'The emperor's transgenic clothes', Are GMO

lemmings in the US leading all of us over the biotechnology cliff?

www.btinternet.com/~nlpwessex/Documents...

4. www.btinternet.com/~nlpwessex/Documents...

5. Oplinger, E.S., M.J. ka, & Schmitz, K.A. (1999) 'Performance of

transgenetic soybeans - Northern US', presented to the ASTA Meetings,

Chicago.

6. Reported in Farmers Weekly (UK), 4th December 1998. , E.A.

(1999) '10 reasons why farmers should think twice before growing GE

crops', www.plant.uoguelph.ca/faculty/eclark/10...

7. Cyran, N. Gully, S., Handl, G., Hofstatter, F. Meyer, Skalicky, M., &

Steinborn, R. (November 11, 2008). Biological effects of transgenic

maize NK603xMON810 fed in long term reproduction studies in mice.

Unpublished report: Institute fur Ernahrung, Austria.

8. Finamore, A., Roselli, M., Britti, S., Monastra, G., AMbra, R., &

Mengheri, E. (In Press). Intestinal and peripheral immune response to

MON810 maize ingestion in weaning and old mice. Journal of Agriculture

and Food Chemistry.

9. Tsuchiya, T.; Fukuda, S.; Hamada, H.; Nakamura, A.; Kohama, Y.;

Ishikawa, H.; Tsujikawa, K.; Yamamoto, H. Role of γδ T cells in the

inflammatory response of experimental colitis mice. Journal of

Immunology. 2003, 171, 5507–5513.

10. Groh, V., Steinle, A., Bauer, S., Spies, T. (1998). Recognition of

stress induced MHC molecules by intestinal epithelial γδ T cells.

Science, 279, 1737–1740.

11. Mombaerts, P., Arnoldi, J., Russ, F., Tonegawa, S., & Kaufmann, S.

H. (1993). Different roles of R and γδ T cells in immunity against an

intracellular bacterial pathogen. Nature, 365, 53–56.

12. Kokkonen, J., Arvonen, M., Va¨ha¨salo, P., & Karttunen, T. J.

(2007). Intestinal immune activation in juvenile idiopathic arthritis

and connective tissue disease. Scandanavian Journal of Rheumatology, 36,

386–389.

13. Pasini, G., Simonato, B., Curioni, A., Vincenzi, S., Cristaudo, A.,

Santucci, B., Peruffo, A. D.; ttasio, M. (2002). IgE-mediated

allergy to corn: a 50 kDa protein, belonging to the reduced soluble

proteins, is a major allergen. Allergy, 57, 98–106.

About the author

Dr. Damato enjoys a vegan lifestyle and runs a Quantum

Biofeedback clinic treating various clients ranging from autism to

cancer. He is currently authoring a book for parents educating on the

many hidden dangers of vaccines, chemical toxicity in toys, GM foods,

the effects of EMFs and EMRs and ways to combat rising childhood illness

and neurological disease by naturally building immunity, detoxification

and nutrition. His goal is to increase global awareness of the myriad of

health issue facing us today and the fact that 100% of them are

preventable and completely reversible.

--

ne Holden, MS, RD

" Ask the Parkinson Dietitian " http://www.parkinson.org/

" Eat well, stay well with Parkinson's disease "

" Parkinson's disease: Guidelines for Medical Nutrition Therapy "

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