Correlation between optimal tacrolimus doses and the graft weight in living donor liver transplantation

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Clinical Transplantation

Volume 16 Issue 2 Page 102 - April 2002

Correlation between optimal tacrolimus doses and the graft weight in living

donor liver transplantation

Y Sugawara, M Makuuchi, J Kaneko, T Ohkubo, H Imamura & H Kawarasaki

The optimal doses of tacrolimus (FK) needed to reach and maintain a target

blood level vary among cases of living donor liver transplantation (LDLT).

One hundred and twenty four LDLTs in 122 patients were included in this

study. Tacrolimus was administered by continuous intravenous infusion at a

rate of 2.5g/kg/h just after the operation. The time needed to reach the

target blood level and the dose needed to maintain this level for 1week

(17-18ng/mL) were defined as the initial duration (ID) and secondary dose

(SD), respectively. In the first 100 LDLTs, the correlations between ID or

SD and some clinical factors were examined and equations for predicting ID

or SD were derived. In the latest 24 LDLTs, FK was administered using these

equations and the actual and calculated ID and SD values were compared. A

multiple regression analysis revealed that only the graft weight/recipient

standard liver volume (GW/SLV) ratio (%) correlated with ID or SD. Stepwise

regression analysis led to the equations ID (h)=0.4GW/SLV ratio + 0.2; SD

(g/kg/h)=0.02GW/SLV ratio - 0.4. Simple regression analysis revealed a

significant correlation between the actual and calculated ID and SD values

(p<0.0001). Initial duration and SD can be estimated from equations using

the GW/SLV ratio.