Selenium Supplementation May Benefit Cardiovascular Health

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Selenium Supplementation May Benefit Cardiovascular Health

http://www.vitasearch.com/CP/weeklyupdates/

Reference: " Selenium supplementation improves antioxidant capacity in

vitro and in vivo in patients with coronary artery disease The Selenium

Therapy in Coronary Artery disease Patients (SETCAP) Study, " Schnabel R,

Lubos E, et al, Am Heart J, 2008; 156(6): 1201.e1-11. (Address: Stefan

Blankenberg, Department of Medicine II, Johannes Gutenberg-University,

Mainz, Germany. E-mail: blankenberg@... ).

Summary: In a study involving in vitro and in vivo trials, selenium

supplementation was found to increase activity of glutathione peroxidase

1 (GPx-1) activity in endothelial cells and in patients with coronary

artery disease. In the cell study involving human coronary artery

endothelial cells, incubation with 5.78 to 578 nmol/L sodium selenite or

Se-methyl-selenocysteine hydrochloride was found to increase GPx-1

protein and activity in a dose-dependent manner. In the human study, 45

patients with coronary artery disease and impaired endothelial function

(FMD<8%) were randomly assigned to receive 200 or 500 microg sodium

selenite daily or matching placebo over a 12 week period. In subjects

given the 200 microg dose, glutathione peroxidase 1 activity increased

from 37.0 U/gHb to 41.1 U/gHb, and in subjects given the 500 microg

dose, glutathione peroxidase 1 activity increased from 38.1 U/gHb to

42.6 U/gHb. No signification differences in FMD o r markers of oxidative

stress and inflammation were found. The authors conclude that selenium

supplementation (sodium selenite) increases GPx-1 activity in cells and

in patients with coronary artery disease. Additional research is needed

to assess the long-term effects of selenium supplementation in patients

with CAD.

--

ne Holden, MS, RD

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