Supplementation with L-Ornithine - a free amino acid - Reduces Physical Fatigue

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Supplementation with L-Ornithine - a free amino acid - Reduces Physical

Fatigue

http://www.vitasearch.com/CP/weeklyupdates/

Reference: " l-Ornithine supplementation attenuates physical fatigue in

healthy volunteers by modulating lipid and amino acid metabolism, "

Sugino T, Shirai T, et al, Nutrition Research, 2008; 28(11): 738-743.

(Address: Osami Kajimoto, Department of Biomarker and Molecular

Biophysics, Osaka City University Graduate School of Medicine, Abeno-ku,

Osaka 545-8585, Japan. E-mail: kajimoto@... ).

Summary: In a double-blind, placebo-controlled, 2-way crossover study

involving 17 healthy volunteers, supplementation with the free amino

acid, l-ornithine (2,000 mg/d for 7 days, and 6,000 mg/d for 1 day as

l-ornithine hydrochloride) for a period of 8 days was found to

significantly reduce subjective feelings of fatigue in women.

Participants were subjected to a fatigue-inducing physical task (cycle

ergometer trials for 2 hours on 2 occasions). Supplementation with

l-ornithine was associated with increases in lipid metabolism and

activation of the urea cycle, and in women, significantly lower feelings

of fatigue. In addition, in women, the decrease in mean speed for 10

seconds maximum pedaling was smaller than that in the group who received

placebo. The authors conclude, " These results suggest that l-ornithine

has an antifatigue effect by increasing the efficiency of energy

consumption and promoting the excretion of ammonia. l-ornithine is a

free am ino acid and is not rich in meats or fish, so it is difficult to

obtain amounts of l-ornithine from ordinary meals that would be

sufficient to promote the antifatigue effect. We recommend l-ornithine

intake as a nutritional supplement in cases of physical fatigue. "

--

ne Holden, MS, RD

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