Vitamins C and E may Reduce Inflammation and Improve Insulin Action

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Vitamins C and E may Reduce Inflammation and Improve Insulin Action

http://www.vitasearch.com/CP/weeklyupdates/

Reference: " Evidence for anti-inflammatory effects of combined

administration of vitamin E and C in older persons with impaired fasting

glucose: impact on insulin action, " Rizzo MR, Abbatecola AM, et al, J Am

Coll Nutr, 2008; 27(4): 505-11. (Address: Second University of Naples,

Department of Geriatric Medicine and Metabolic Diseases, Naples, Italy).

Summary: In a study involving 13 older men with impaired fasting

glucose, supplementation with vitamin C (1000 mg/d) and vitamin E (1000

IU/d) for a period of 4 weeks was found to reduce inflammation and

improve insulin action through a rise in non-oxidative glucose

metabolism. Before and after supplementation, hyperinsulinemic

euglycemic glucose clamp was performed. In patients who received

supplementation, increases in plasma vitamins E and C were found.

Moreover, reductions in insulin, glucose, lipid, TNF-alpha, and

[8-]isoprostane levels were found as well. Increases in plasma vitamin E

levels were associated with reductions in plasma [8-]isoprostane levels

and TNF-alpha levels. Increases in whole body glucose disposal and

non-oxidative glucose metabolism were found after supplementation as

well, which correlated with increases in plasma levels of vitamins C and

E. These results suggest that supplementation with vitamins C and E may

be nefit patients with impaired fasting glucose.

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