Vitamin B6 Deficiency in Schizophrenic Patients with Tardive Dyskinesia

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Vitamin B6 Deficiency in Schizophrenic Patients with Tardive Dyskinesia

http://www.vitasearch.com/CP/weeklyupdates/

Reference: " Pyridoxal plasma level in schizophrenic and schizoaffective

patients with and without tardive dyskinesia, " Miodownik C, Meoded A, et

al, Clin Neuropharmacol, 2008; 31(4): 197-203. (Address: Division of

Psychiatry, Ministry of Health Be'er Sheva Mental Health Center, Faculty

of Health Sciences, Ben-Gurion University of the Negev, Be'er-Sheva,

Israel).

Summary: In a study involving 89 schizophrenic inpatients - 40 with

tardive dyskinesia (TD) (22 men, 18 women), and 49 without any symptoms

of motor disturbances (30 men, 19 women) - plasma pyridoxal-5-phosphate

(PLP) levels - an indicator of vitamin B6 status - were found to be

significantly lower in male schizoaffective patients with TD (12.4 nM),

as compared to male patients without TD (29.0 nM). These results suggest

that vitamin B6 " may ameliorate different drug-induced movement

disorders, including tardive dyskinesia (TD). " Additional research is

warranted.

--

ne Holden, MS, RD

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