Inositol Tolerance

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Inositol Tolerance

High-histamine depressives overproduce and retain excessive levels of histamine,

an important neurotransmitter which affects human behavior. They are

under-methylated resulting in generalized low levels of important

neurotransmitters such as serotonin. This syndrome often involves seasonal

variations in depression, obsessive-compulsive behavior, inhalant allergies, and

frequent headaches. Biochemical treatment revolves around antifolates,

especially calcium and methionine. Three to six month of nutrient therapy are

usually needed to correct this chemical imbalance. As in most biochemical

therapies, the symptoms usually return if treatment is stopped.

Supplements appropriate for high histamine/undermethylation:

Methionine, SAM-e, calcium, magnesium, omega-3 essential oils (DHA & EPA), B-6,

INOSITOL, and vitamins A, C, and E. Avoid supplements containing folic acid.

Low-histamine depressives are usually nervous, anxious individuals who are prone

to paranoia and despair. They are over-methylated which results in elevated

dopamine and norepinephrine levels. Although free of seasonal allergies, they

often report a multitude of food and chemical sensitivities. Many have a history

of hyperactivity, learning disabilities, and underachievement. Treatment focuses

on use of folic acid together with niacinamide and vitamin B-12, with about 2-4

months required for correction of the imbalance.

Supplements appropriate for low histamine:

folic acid, B-12, niacinamide, DMAE, choline, manganese, zinc, omega-3 essential

oils (DHA and EPA) and vitamins C and E. AVOID supplements of methionine, SAMe,

INOSITOL, TMG and DMG.

Pyroluria is a stress disorder characterized by pronounced mood swings, temper

outbursts, and anxious depression. Many pyrolurics report an inability to eat

breakfast, absence of dream recall, and frequent infections. Treatment centers

on correcting a double deficiency of B-6 and zinc, which is believed to result

from abnormal hemoglobin synthesis that depletes the body of these nutrients. A

positive response often occurs within the first 7 days of treatment, with 1-2

months usually required for correction of the imbalance.

Supplements appropriate for Pyroluria :

Zinc, B-6, Primrose Oil (in addition to a good foundation of others) High-copper

depressives usually have a history of hyperactivity, tinnitus, and skin

sensitivity to metals. Females with this condition usually have significant PMS

and are prone to heightened depression during hormonal events such as childbirth

and menopause. They often report a worsening of depression after estrogen or

multiple vitamins. Treatment focuses on release of excess copper from tissues,

promotion of copper excretion, and stimulation of metallothionein (a

metal-binding protein). Caution must be exercised due to the tendency of blood

copper levels to rise during the first 10 days of treatment. Many patients

report a mild worsening over the first 3 weeks, followed by steady improvement.

A total of 60 to 90 days is usually required to correct this imbalance.

Regards,