RESEARCH - Upper GI disorders induced by NSAIDs

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Inflammopharmacology. 2008 Feb;16(1):16-20.

Upper gastrointestinal disorders induced by non-steroidal

anti-inflammatory drugs.

Chiba T, Sato K, Kudara N, Shinozaki H, Ikeda K, Sato K, Endo M, Orii

S, Suzuki K.

First Department of Internal Medicine, Iwate Medical University, 19-1

Uchimaru, Morioka, Iwate, 020-8505, Japan.

AIMS: We examined the characteristics of upper gastrointestinal

disorders induced by non-steroidal anti-inflammatory drugs (NSAIDs).

METHODOLOGY: The questionnaire investigation was performed over a five

year period. RESULTS: A study was performed on 354 patients (161 men

and 193 women with mean ages of 66.0 and 70.7 years, respectively) who

developed NSAIDs associated upper GI disorders: 21 patients had AGML,

212 had gastric ulcer, 63 had duodenal ulcer, 17 had gastroduodenal

ulcers and 41 other cases. About 75 % of patients received NSAIDs for

orthopedic conditions. Sixty percent of gastric disorders induced by

NSAIDs affected the antrum or angulus of the stomach. The incidence of

disorders of the gastric antrum was significantly higher in women than

in men whilst the incidence of disorders on the gastric angulus was

significantly higher in men than in women (p < 0.05). The proportion

of patients with abdominal pain was significantly lower in patients

over 65 years old than in those under 65 years old, and the proportion

of patients with hematemesis or melena was significantly higher in

patients over 80 years old than in those under 80 years old (p <

0.05). The time taken to achieve the healing stage was significantly

longer in patients with greater than 3 months NSAIDs ingestion

compared to patients that had received NSAIDs for less than 3 months

(p < 0.05).

CONCLUSIONS: Patients 65 years old and over with continuous NSAIDs use

had asymptomatic ulcers, and patients 80 years old and over had

hemorrhagic ulcers.

PMID: 18256801

http://www.ncbi.nlm.nih.gov/pubmed/18256801

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