Coenzyme Q10, Riboflavin, and Niacin Show Anti-Angiogenic Properties in Breast Cancer Patients

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Coenzyme Q10, Riboflavin, and Niacin Show Anti-Angiogenic Properties in

Breast Cancer Patients

http://www.vitasearch.com/CP/weeklyupdates/

Reference: " Anti-angiogenic potential of CoenzymeQ10, riboflavin and

niacin in breast cancer patients undergoing tamoxifen therapy, "

Premkumar VG, Yuvaraj S, et al, Vascul Pharmacol, 2008; 48(4-6):

191-201. (Address: Department of Medical Biochemistry, DR. A.L.M.

Post-Graduate, Institute of Basic Medical Sciences, University of

Madras, Taramani Campus, Chennai, India. E-mail:

psachdanandam_2000@... ).

Summary: In a randomized study involving 84 breast cancer patients,

daily supplementation with coenzyme Q10 (100 mg), riboflavin (10 mg),

and niacin (50 mg), in addition to standard treatment with the

chemotherapy drug, tamoxifen (10 mg, twice/day), for a period of 45 days

or 90 days, was found to reduce levels of pro-angiogenic factors and

increase levels of anti-angiogenic factors, thereby potentially reducing

the risk of cancer metastases and cancer recurrence. Breast cancer

patients who were untreated were found to have elevated levels of serum

pro-angiogenic factors, while those receiving tamoxifen for 1 year were

found to have reduced levels. When the nutritional supplementation

combination was added to the tamoxifen, angiogenesis markers were

further improved. The authors conclude, " A reduction in pro-angiogenic

marker levels attributes to reduction in tumor burden and may suggest

good prognosis and efficacy of the treatment, and migh t even offer

protection from cancer metastases and recurrence. "

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ne Holden, MS, RD

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