Another study showing no link between selenium and prostate cancer

December 20, 2008

This one is interesting as it reached the same conclusions as the large

SELECT study, this time by examining actual selenium concentrations in

blood, not in dietary intake.

The Best to You and Yours!

Jon in Nevada

--------------------------------------------------------------------

Plasma Selenium Concentration and Prostate Cancer Risk: Results from the

European Prospective

Investigation into Cancer and Nutrition (EPIC) - Abstract

Friday, 19 December 2008

NE, Appleby PN, Roddam AW, Tjønneland A, sen NF, Overvad K,

Boeing H, Weikert S, Kaaks R, Linseisen J, Trichopoulou A, Misirli G,

Trichopoulos D, Sacerdote C, Grioni S, Palli D, Tumino R,

Bueno-de-Mesquita HB, Kiemeney LA, Barricarte A, Larrañaga N,

Sánchez MJ, Agudo A, Tormo MJ, L, Stattin P, Hallmans G,

Bingham S, Khaw KT, Slimani N, Rinaldi S, Boffetta P, Riboli E, Key TJ

Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom.

Some evidence indicates that a low selenium intake may be associated

with an increased risk of prostate cancer.

The aim of this study was to investigate the association of plasma

selenium concentration with subsequent prostate cancer risk and to

examine this association by stage and grade of disease and other

factors.

A nested case-control study was performed among men in the European

Prospective Investigation into Cancer and Nutrition (EPIC). The

association between plasma selenium concentration and prostate cancer

risk was assessed in 959 men with incident prostate cancer and 1059

matched controls.

Overall, plasma selenium concentration was not associated with prostate

cancer risk; the multivariate relative risk for men in the highest fifth

of selenium concentration compared with the lowest fifth was 0.96 (95%

CI: 0.70, 1.31; P for trend = 0.25). There were no significant

differences in the association of plasma selenium with risk when

analyzed by stage or grade of disease. Similarly, the association of

selenium with risk did not differ by smoking status or by plasma alpha-

or gamma-tocopherol concentration.

Plasma selenium concentration was not associated with prostate cancer

risk in this large cohort of European men.

Reference: Am J Clin Nutr. 2008 Dec;88(6):1567-75.

PubMed Abstract PMID:19064517

Recommended Posts