REVIEW - Pharmacological treatment of fibromyalgia

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Reumatismo. 2007 Oct-Dec;59(4):280-91.

Pharmacological treatment of fibromyalgia.

Cazzola M, Sarzi-Puttini P, Buskila D, Atzeni F.

U.O. Reumatologia, Azienda Ospedaliera " L. Sacco " , 20157 Milano, Italia.

Fibromyalgia syndrome (FM) is a condition of chronic and diffuse

muscular pain affecting particularly middle aged women. The aetiology

of FM is not completely understood and it is currently considered a

disorder of pain regulation. The most efficacious compounds include

the tricyclic drugs and mixed reuptake inhibitors. Recent works

suggest that the anticonvulsant medications pregabalin and gabapentin

are also effective. Moreover, two serotonin and

norepinephrine-reuptake inhibitors-duloxetine and milnacipran show

encouraging results in treating FM symptoms. The results of clinical

trials of anti-inflammatory medications have been generally

disappointing, but three RCTs have found that tramadol (with or

without acetaminophen) is effective in FM.

PMID: 18157284

http://www.ncbi.nlm.nih.gov/pubmed/18157284

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Not an MD