ERG Maps & Gene-Expression Profiles Show 2 Distinct Types of PCa

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The expression profiles showed clustering, in unsupervised hierarchical

analyses, into two distinct prostate cancer categories, with one group

strongly associated with indicators of poor clinical outcome. The two

categories are not tightly linked to ERG status. By analysis of the

data we identified a subgroup of cancers lacking ERG rearrangements

that showed an outlier pattern of SPINK1 mRNA expression. There was a

major distinction between ERG rearranged and non-rearranged cancers

that involves the levels of expression of genes linked to exposure to

beta-oestradiol, and to retinoic acid....Click on the below link for the full story:<http://www.urotoday.com/61/browse_categories/prostate_cancer/integration_of_erg_gene_mapping_and_geneexpression_profiling_identifies_distinct_categories_of_human_prostate_cancer__abstract.html>