Re: cetyl myristoleate (CMO)

[Guest guest]

** Looks like an essential fatty acid - essential to osteoarthritis sufferers at

least - buy up if you can afford it would be my understanding - topically or

orally some benefit found. In a review article - #8, the last one in this list

found MSM to be more effective then CMO. I don't know how expensive the CMO is

but MSM isn't too bad.

1.

http://www.nutraingredients-usa.com/Research/Cetylated-fatty-acid-enables-osteoa\

rthritis-sufferers-to-exercise-shows-study

Cetylated fatty acid enables osteoarthritis sufferers to exercise, shows study

2.

http://www.nutraingredients-usa.com/Research/Science-The-emerging-ingredients-fo\

r-joint-health

Science: The emerging ingredients for joint health, By ls,

20-Apr-2010 " New Jersey-based Proprietary Ingredients has also been building the

science behind its cetylated fatty acid branded ingredient Celadrin. The

ingredient has been reported to offer an alternative to NSAIDs when taken orally

(J. Rheumatol. 2002, Vol. 29, pp. 1708-1712), and efficacy has also been

reported for a topical application J. Rheumatol. 2004, Vol. 31, pp. 767-774).

Results of a randomised clinical trial presented at the Scripps Integrated

Medical Conference in San Diego in 2007 reported that the ingredient was

effective at reducing knee pain in subjects with moderate osteoarthritis,

compared with placebo. "

3.

http://www.nutraingredients-usa.com/smartlead/view/273265/4/Biocell-Technology-L\

LC-Novel-Dietary-Ingredients

EstraFlexâ„¢ CMO Esterfied Fatty Acid Carbons (EFAC) - A proprietary blend of

cetylated fatty acids, including cetyl myristate, cetyl myristoleate, cetyl

oleate, cetyl palmitoleate, and cetyl palmitate.

4. http://www.ncbi.nlm.nih.gov/pubmed/15088305 Effect of a cetylated fatty acid

topical cream on functional mobility and quality of life of patients with

osteoarthritis. 2004 article

CONCLUSION: Use of a CFA topical cream is an effective treatment for improving

knee ROM, ability to ascend/descend stairs, ability to rise from sitting, walk

and sit down, and unilateral balance.

5. http://www.aafp.org/afp/2003/0115/p339.html 2003 article Alternative

Therapies for Traditional Disease States: Osteoarthritis Am Fam

Physician. 2003 Jan 15;67(2):339-344.

Cetyl Myristoleate

A new agent promoted for osteoarthritis treatment is cetyl myristoleate, a

material synthesized from cetyl alcohol and myristoleic acid. The rationale for

its use in osteoarthritis stems from the hypothesis that cetyl myristoleate may

inhibit the cyclooxygenase and lipoxygenase pathways of arachidonic acid

metabolism and, therefore, decrease production of pro-inflammatory

prostaglandins and leukotrienes.

6. http://www.ncbi.nlm.nih.gov/pubmed/8207671

Diehl, HW, May EL, Cetyl myristoleate isolated from Swiss albino mice: an

apparent protective agent against adjuvant arthritis in rats., J Pharm Sci. 1994

Mar;83(3):296-9.

Abstract

Cetyl myristoleate was isolated from National Institutes of Health, general

purpose, Swiss albino mice that were immune to the polyarthritis induced in

rats with Freund's adjuvant. This substance, or material synthesized from cetyl

alcohol and myristoleic acid, afforded good protection against adjuvant-induced

arthritic states in rats. In limited comparisons, cetyl oleate, also found in

Swiss albino mice, gave lesser protection, whereas cetyl myristate and cetyl

elaidate, the trans-isomer of cetyl oleate, appeared to be virtually

ineffective. Dosage of the protective compound as well as the site of injection

of Freund's adjuvant was important.

7. http://www.ncbi.nlm.nih.gov/pubmed/12526860

Hunter KW Jr, Gault RA, Stehouwer JS, Tam-Chang SW, Synthesis of cetyl

myristoleate and evaluation of its therapeutic efficacy in a murine model of

collagen-induced arthritis., Pharmacol Res. 2003 jan;47(1):43-7. Department of

Microbiology, University of Nevada School of Medicine, Reno, NV 89557, USA.

khunter@...

Abstract

Cetyl myristoleate (CM) was reported by Diehl and May [J Pharm Sci 83 (1994)

296] to block inflammation and prevent adjuvant-induced arthritis in rats. To

verify this earlier work, we have synthesized pure CM and tested its

anti-arthritic properties in a collagen-induced arthritis model in DBA/1LacJ

mice. Multiple intraperitoneal injections of CM in 450 and 900 mg kg(-1) doses

resulted in a significantly lower incidence of disease and caused a modest but

significant diminution in clinical signs in those mice that developed

arthritis. CM administered in daily oral doses of 20 mg kg(-1) also reduced the

incidence of arthritis and caused a small reduction in the clinical signs in

mice that developed arthritis. Although the protective effect of CM in

collagen-induced arthritis observed in the present study was less dramatic than

that reported earlier, our results confirm the anti-arthritic properties of

pure CM.

8. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779427/?tool=pubmed

Osteoarthritis and nutrition. From nutraceuticals to functional foods: a

systematic review of the scientific evidence t G Ameye and Winnie SS Chee

free article - Table three compares the various things they reviewed.

The oil cetyl myristoleate is the hexadecyl ester of the unsaturated fatty

acid cis-9-tetradecenoic acid, commonly named myristoleic acid. Whereas

myristoleic acid is commonly found in fish oils, whale oils, and dairy butter,

cetyl myristoleate is known to exist only naturally in sperm whale oil and in a

small gland in the male beaver. It can be synthesised by esterification of

myristoleic acid. Although cetyl myristoleate is claimed to be beneficial for

OA, there is lack of scientific evidence to support its efficacy. Nevertheless,

a 68-day placebo-controlled single-blind RCT on severe knee OA (that is, LFI

>14) concluded that three 500 mg capsules, containing 350 mg of a blend of

olive oil and various cetylated fatty acids, 50 mg of lecithin, and 75 mg of

fish oil, twice a day, significantly increased knee flexion compared with

placebo [50] (Table 4). According to the best-evidence synthesis (Table 3),

this low-quality RCT provides limited scientific evidence of efficacy for cetyl

myristoleate. Hence, further research is needed to evaluate the safety and

potential benefits of cetyl myristoleate and cetylated fatty acids in the

treatment of OA.

In summary, this review demonstrates that nutrition can improve the symptoms of

declared OA. However, the role of nutrition in slowing down progression of the

disease remains to be seen. The very few RCTs, which used structure-modifying

variables as primary endpoints, were unable to demonstrate a benefit, but the

area deserves further investigation. As a whole, nutritional research in OA is

only in its infancy. Only a few ingredients have been tested, and research

remains based mainly on a pharmacological type of approach (one molecule/one

target) rather than on a nutritional, more holistic type of approach (multiple

ingredients/multiple targets). The full potency of nutrition for patients with

declared OA thus remains to be evaluated. In parallel, and except for a few

longitudinal epidemiological studies on vitamins, no study has evaluated the

value of nutrition in the prevention of OA.

** Nice summary, I don't see that kind of statement often.

R Vajda, R.D.

www.GingerJens.com

________________________________

To: rd-usa

Sent: Mon, March 7, 2011 3:23:10 PM

Subject: cetyl myristoleate (CMO)

I am looking for input on a supplement called Cetyl Myristoleate (CMO) that my

brother started taking for his knees that are in constant pain from numerous

surgeries, he was told by a physical therapist where he lives i n MD about this

and he said he has had immediate and almost complete relief from pain, I am

going to check with the Natural Database online reference, but wondered if

anyone has had any experience with it. My daughter has inherited the bad knees,

and I have degenerative disc disease in my spine that hasn't responded to much,

was wondering about possibility of it helping both of us also, I am cautious

about taking things without some reading into it. thanks in advance. Sue

Nichols

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Sue Nichols, MS/RD/CDE/CDN