Re: Re: Need help with newly-dx pre-DM/PCOS

[Guest guest]

I mean no disrespect, nor do I mean to suggest any expertise - I am suggesting

that there may be underlying dysfunction that makes it more difficult to lose

weight and easier to gain weight. knowing where the dysfunction lies would help

target nutritional approaches to make the battle easier. Information is power.

I am not suggesting that weight loss for those who do need to lose weight is

easy - especially given the current strategies being recommended. Based on my

review of some PCOS research, I do believe the underlying disorder is related to

nutrient deficiency. Someone who does manage to lose weight would also have

managed to work through changing some habits that led to the weight gain. Weight

loss seemed like a trend in successful cases that I wasn't seeing as thoroughly

for some of the meds - Metformin helps a fair amount it sounded like but if it

can help promote a pregnancy without supporting a live birth than it isn't a

good solution.

I just found this article that is relating PCOS with hyper parathyroidism and

high levels of 1,25 D

http://www.clinchem.org/cgi/content/full/52/6/12

1. Ashish A. Sule and Melvin Khee Shing Leow, “Association of Polycystic

Ovary Syndrome and Fibromyalgia in a Patient with Primary Hyperparathyroidism: A

Novel Triad?,†Clin Chem 52, no. 6 (June 1, 2006): 1208-1209.

Panidis et al. (1) surmised that increased serum PTH is relatedto PCOS, a theory

that was applicable in our case. However,the converse is equally compelling,

given that dysregulatedbalance of calcium and vitamin D can perturb oocyte

maturation,leading to meiotic arrest. In a series of women with PCOS

andhypovitaminosis D–related secondary hyperparathyroidism,repletion of

vitamin

D with calcium normalized the menstrualcycles within 2 months in 7 of 13 women

(4). Our patient’sprofile differed because her low vitamin D stores,

increasedPTH, and hypercalcemia were synchronous, suggesting that

herhypercalcemia was fueled by hyperparathyroidism, as supportedby the

hypercalciuria in conjunction with low serum phosphate.The low 25-hydroxyvitamin

D3 in our patient may also have beencaused by increased conversion to

1,25-dihydroxyvitamin D3 byPTH-augmented 1- hydroxylation.

Diagnosis of primary hyperparathyroidism should precede diagnosisof PCOS if it

is central to the pathogenesis of PCOS. In ourpatient, PCOS was diagnosed first,

but normocalcemic hyperparathyroidismmay have triggered her PCOS initially,

whereas hypovitaminosisD probably masked the primary hyperparathyroidism and

contributedto its delayed detection. PCOS with fibromyalgia has not

beendescribed in the existing literature. Nevertheless, women withendometriosis

tend to have fibromyalgia (5). PCOS and endometriosismight appear as disparate

entities, but they lie along the samecontinuum, sharing intricate connections

(6). We believe thisassociation of PCOS, fibromyalgia, and primary

hyperparathyroidismqualifies as a distinct triad, beyond mere coincidence,

andmerits further investigations.

this case had low 25-D and high 1-25 D. Supplementing with 25 D will give short

term relief because it is acting as a corticosteroid - Tx that is used in PCOS.

Just not a long term solution for a 14 y/o who wants children or a normal life.

So based on the Norma Parathyroid Center research - I would think the

hypercalcemia combined with the depressed 25 D and elevated 1-25 D would suggest

that there may be a cancer tumor in the parathyroid gland in PCOS. I tended to

be hypocalcemic which can be a reaction to hypomagnesemia - I think I have

chroinic infection not cancer - the bonus of cancer in this case would be that

success the Norman Parthyroid center has had woith the depressed 25 D levels

normalizing soon after the tumor is removed - under any equatorial sun

conditions - 10000 patients around the world.

1. . Politz D, Norman J., Hyperparathyroidism in patients over 80: clinical

characteristics and their ability to undergo outpatient parathyroidectomy

(Thyroid.2007 Apr;17(4):333-9.)

2. Norman J,Low Vitamin D does not cause high calcium, by ParathyroidTV,

posted on YouTube, Norman Parathyroid Center

R Vajda, R.D.

www.GingerJens.com

________________________________

To: rd-usa

Sent: Thu, March 10, 2011 12:31:52 AM

Subject: Re: Need help with newly-dx pre-DM/PCOS

ne,

I invite your niece to visit our network blog, www.incyst.com. I post

testimonials whenever I receive them, just put one up last week from someone

wh's made good progress simply from reading the blog and listening to the radio

episodes.

From there she can link to our Facebook fan page (inCYST Programs for Women with

PCOS) as well as to episodes of our radio program which are very lay-centric. I

even conducted a sample counseling session with a client so women could become

familiar with what to expect when working with a dietitian.

Many of our network members also conduct Skype counseling, she can look through

the list of options at www.afterthediet.com/pcoshelp.htm

I apologize for having things scattered across two different sites; I am

currently working on consolidating everything.

A crucial point of clarification: Weight loss is NOT the primary recommendation

we should be making. Up to 70% of women with PCOS are not overweight and are

practicing disordered eating as an unhealthy attempt at self-medication. Being

overweight does not cause PCOS; it does, however worsen symptoms if they are

there.

The absolute worst thing you can do to your credibility with women with PCOS is

to jump on the preaching weight loss bandwagon. If they could have figured that

out, as smart, well-informed, and hard working as most of them are, they

wouldn't be coming to you asking for help.

Monika M. Woolsey, MS, RD

http://www.afterthediet.com

[Guest guest]

> ne,

>

> I invite your niece to visit our network blog, www.incyst.com. I

> post testimonials whenever I receive them, just put one up last week

> from someone wh's made good progress simply from reading the blog and

> listening to the radio episodes.

Monika, thanks; I did not know of your blog, and have passed that on to

her. She sends her thanks and I do, too.

> Many of our network members also conduct Skype counseling, she can

> look through the list of options at

> www.afterthediet.com/pcoshelp.htm

That is super -- much more than I had hoped for, and so much appreciated.

> The absolute worst thing you can do to your credibility with women

> with PCOS is to jump on the preaching weight loss bandwagon. If they

> could have figured that out, as smart, well-informed, and hard

> working as most of them are, they wouldn't be coming to you asking

> for help.

Monika, it was not I, but her doctor, who directed her to lose weight. I

am guessing that the Dr figures it may control the pre-DM, but that's

just a guess.

Again, I appreciate your response more than I can say, and will pass on

these further comments.

Thanks,

ne

[Guest guest]

> Hi ne,

>

> I was out of the office and emails piled up while I was gone. Sorry

> for the delayed response.

>

> It is always a privelege to help someone with PCOS. I know these

> women have gone through much before finding us, much of it not

> helpful, insightful, or respectful. I hope what we've put together

> is helpful, and that anything that is not answered is something you

> know you can ask us about.

Monika, she was very grateful for the help. Almost all of the

information you passed on is entirely new to her (well, and to me as

also) and it was enlightening. Due to her doctor, she was mainly

concerned about the pre-DM and need for weight loss; she had received

virtually no information re PCOS. I did not know to give precedence to

PCOS over pre-DM, so I learned as well. She has expressed her gratitude,

which I pass on to you and the others who helped. Thank you so much!

Best,

ne

[Guest guest]

Yup, one has to see Monika in action...

Sent from my Verizon Wireless BlackBerry

Re: Re: Need help with newly-dx pre-DM/PCOS

> Hi ne,

>

> I was out of the office and emails piled up while I was gone. Sorry

> for the delayed response.

>

> It is always a privelege to help someone with PCOS. I know these

> women have gone through much before finding us, much of it not

> helpful, insightful, or respectful. I hope what we've put together

> is helpful, and that anything that is not answered is something you

> know you can ask us about.

Monika, she was very grateful for the help. Almost all of the

information you passed on is entirely new to her (well, and to me as

also) and it was enlightening. Due to her doctor, she was mainly

concerned about the pre-DM and need for weight loss; she had received

virtually no information re PCOS. I did not know to give precedence to

PCOS over pre-DM, so I learned as well. She has expressed her gratitude,

which I pass on to you and the others who helped. Thank you so much!

Best,

ne