RESEARCH - Corticosteroid use in pregnancy and the risk of cleft palate

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Am J Med Genet. 1999 Sep 17;86(3):242-4.

Maternal corticosteroid use and risk of selected congenital anomalies.

http://www.ncbi.nlm.nih.gov/pubmed/10482873

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Teratology. 2000 Dec;62(6):385-92.

Birth defects after maternal exposure to corticosteroids: prospective

cohort study and meta-analysis of epidemiological studies.

http://www.ncbi.nlm.nih.gov/pubmed/11091360

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Am J Med Genet A. 2003 Aug 1;120(4):459-63.

Case-control study of cleft lip or palate after maternal use of

topical corticosteroids during pregnancy.

http://www.ncbi.nlm.nih.gov/pubmed/12884422

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Am J Obstet Gynecol. 2007 Dec;197(6):585.e1-7; discussion 683-4, e1-7.

Maternal corticosteroid use and orofacial clefts.Carmichael SL, Shaw

GM, Ma C, Werler MM, Rasmussen SA, Lammer EJ; National Birth Defects

Prevention Study.

March of Dimes Foundation/California Department of Health Services,

California Birth Defects Monitoring Program, Berkeley, CA, USA.

SCarmichael@...

OBJECTIVE: The purpose of this study was to examine whether maternal

corticosteroid use during pregnancy is associated with delivering an

infant with an orofacial cleft. STUDY DESIGN: This study included data

on deliveries from the National Birth Defects Prevention Study, which

is a population-based case-control study. Exposures were assessed by

telephone interviews for mothers of 1141 cases with cleft lip +/-

cleft palate (CLP), 628 with cleft palate (CP), and 4143 controls.

RESULTS: Mothers of 33 infants with CLP (2.9%), mothers of 6 infants

with CP (1.0%), and 72 control subjects (1.7%) reported corticosteroid

use from 4 weeks before through 12 weeks after conception. The crude

odds ratio for " any " vs " no " use was 1.7 (95% CI, 1.1-2.6) for CLP and

0.5 (0.2-1.3) for CP. When analyzed by route of administration and

medication components, odds ratios for CLP tended to be elevated, and

odds ratios for CP tended to be close to 1. CONCLUSION: Our results

suggest a moderately increased risk of CLP among women who use

corticosteroids during early pregnancy.

PMID: 18060943

http://www.ncbi.nlm.nih.gov/pubmed/18060943

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Not an MD