Nutritional Supplement Boosts Cognition in Healthy Women

[Guest guest]

*My note: Never heard of it????*

Citicoline, a naturally occurring substance found in the brain and liver and

marketed as a nutritional supplement, enhanced aspects of cognition in

healthy women and may have a role in mitigating the cognitive decline

associated with normal aging, new research suggests.

It may also improve the attention deficits associated with psychiatric

disorders, said McGlade, PhD, from the University of Utah Brain

Institute, Salt Lake City, who led the study.

" We chose to study citicoline because in prior research it showed

cognitive-enhancing effects with very few side effects, which is very

important when using a supplement, " Dr. McGlade told *Medscape Medical News*

..

" We think these changes in cognition include improvement in attention,

perhaps due to an increase in brain dopamine levels, but findings regarding

dosing in healthy individuals have not been conclusive. "

The study was presented here at the New Clinical Drug Evaluation Unit

(NCDEU) 51st Annual Meeting, sponsored by the American Society of Clinical

Psychopharmacology (ASCP).

*Improvement 'Noteworthy' *

Dr. McGlade and colleagues recruited 60 women age 40 to 60 years and

screened them to rule out axis 1 or axis 2 psychiatric disorders, as well as

any kind of cognitive deficits beyond the average cognitive decline

associated with aging.

The women were divided into 3 groups of 20 and randomly assigned to receive

a daily oral citicoline dose of 250 mg (low dose) or 500 mg (high dose) or

placebo for 28 days.

They were evaluated with the Continuous Performance Test II (CPT-II) to

measure attention functioning just after randomization and at the end of the

study period.

The investigators found that participants who received low- or high-dose

citicoline showed improved attention, demonstrating fewer commission and

omission errors on the CPT-II compared with the placebo group.

" Women receiving the supplement made fewer errors in response to nontarget

stimuli over the course of the study, " Dr. McGlade said.

" Interestingly, the 250 dose produced similar results to the larger dose.

The improvement was quite noteworthy, with a *P* value equal to .02 for the

250-mg dose and a *P* value equal to .03 with the 500-mg dose, and this was

just after 28 days, so the effect was relatively rapid as well, " she said.

It is important to know that a supplement such as citicoline can affect

attention without side effects, she added.

Future work will determine the utility of citicoline in psychiatric

disorders to see whether it will lessen some of the associated attention

deficits that are associated with these disorders, Dr. McGlade said.

*Large Potential Market*

Citicoline is one of the few pyrimidines available as a nutritional

supplement in the United States and Canada, noted Renshaw, MD, PhD,

professor of psychiatry at the University of Utah, Salt Lake City.

" Among other things, pyrimidines increase brain phospholipid synthesis,

which is responsible for the therapeutic efficacy of citicoline as a

treatment for stroke and head trauma, and they also increase catecholamine

synthesis, which probably is responsible for citicoline’s effect on

attention, " said Dr. Renshaw, who was not part of the current study.

" The study by McGlade and colleagues is significant in that it documents

pro-attentional effects at a dose as low as 250 mg. Pharmaceutical doses as

high as 4000 mg have been evaluated. If this effect can also be documented

in other populations, such as children and teens, it suggests that

citicoline would have a large market in the brain health area, " he said.

*The study was funded by Kyowa Hakko Bio Co., Ltd, the manufacturers of the

citicoline that was used in the study. Dr. McGlade has disclosed no relevant

financial relationships. Dr. Renshaw has reported financial relationships

with Ridge Diagnostics and Kyowa Hakko.*

New Clinical Drug Evaluation Unit (NCDEU) 51st Annual Meeting, sponsored by

the American Society of Clinical Psychopharmacology (ASCP). Abstract # 50.

Presented June 14, 2011.www.medscape.com

From Natural medicine database:<http://naturaldatabase.therapeuticresearch.com>

Editor's Comments: [image: return to

top]<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?rn=4 & cs= & s=ND\

& pt=100 & id=1090 & ds= & name=CITICOLINE & searchid=27875534#top>

Citicoline was originally developed in Japan for acute cerebrovascular

events. Citicoline was eventually introduced as a prescription drug in many

European countries. In these countries it is now frequently prescribed for

cognitive impairment related to chronic cerebrovascular disease . In the US

citicoline is marketed as a dietary supplement and is often promoted for

age-related cognitive impairment.

--

Ortiz, MS, RD

*The FRUGAL Dietitian* <http://www.thefrugaldietitian.com>

Check out my blog: mixture of deals and nutrition

Join me on Facebook <http://www.facebook.com/TheFrugalDietitian?ref=ts>

CONGRATS to my parents for 65 years of wedded bliss June 22,

1946<http://thefrugaldietitian.com/?p=22359>

Join Crowdtap: Earn gift cards, try out products, support your charity…All

for FREE!!! <http://thefrugaldietitian.com/?p=21973>Polo Shirt with your

logo: $2.95 shipped <http://thefrugaldietitian.com/?p=20750> * " Nutrition is

a Science, Not an Opinion Survey " *

[Guest guest]

The 1st time I heard of citicoline was last week from a patient that his family

doctor prescribed Somazina because he felt tired and with concentration

problems. I didn't have time yet to look more into it.

Patient experience: I took this for 1 month and didn't change anything.

" Citicoline (INN), also known as cytidine diphosphate-choline (CDP-Choline) &

cytidine 5'-diphosphocholine is a psychostimulant/nootropic. It is an

intermediate in the generation of phosphatidylcholine from choline. Sold in over

70 countries under a variety of brand names: Ceraxon, Cognizin, NeurAxon,

Somazina etc "

Catia Borges

>

> *My note: Never heard of it????*

>

> Citicoline, a naturally occurring substance found in the brain and liver and

> marketed as a nutritional supplement, enhanced aspects of cognition in

> healthy women and may have a role in mitigating the cognitive decline

> associated with normal aging, new research suggests.

>

> It may also improve the attention deficits associated with psychiatric

> disorders, said McGlade, PhD, from the University of Utah Brain

> Institute, Salt Lake City, who led the study.

>

> " We chose to study citicoline because in prior research it showed

> cognitive-enhancing effects with very few side effects, which is very

> important when using a supplement, " Dr. McGlade told *Medscape Medical News*

> .

>

> " We think these changes in cognition include improvement in attention,

> perhaps due to an increase in brain dopamine levels, but findings regarding

> dosing in healthy individuals have not been conclusive. "

>

> The study was presented here at the New Clinical Drug Evaluation Unit

> (NCDEU) 51st Annual Meeting, sponsored by the American Society of Clinical

> Psychopharmacology (ASCP).

>

> *Improvement 'Noteworthy' *

>

> Dr. McGlade and colleagues recruited 60 women age 40 to 60 years and

> screened them to rule out axis 1 or axis 2 psychiatric disorders, as well as

> any kind of cognitive deficits beyond the average cognitive decline

> associated with aging.

>

> The women were divided into 3 groups of 20 and randomly assigned to receive

> a daily oral citicoline dose of 250 mg (low dose) or 500 mg (high dose) or

> placebo for 28 days.

>

> They were evaluated with the Continuous Performance Test II (CPT-II) to

> measure attention functioning just after randomization and at the end of the

> study period.

>

> The investigators found that participants who received low- or high-dose

> citicoline showed improved attention, demonstrating fewer commission and

> omission errors on the CPT-II compared with the placebo group.

>

> " Women receiving the supplement made fewer errors in response to nontarget

> stimuli over the course of the study, " Dr. McGlade said.

>

> " Interestingly, the 250 dose produced similar results to the larger dose.

> The improvement was quite noteworthy, with a *P* value equal to .02 for the

> 250-mg dose and a *P* value equal to .03 with the 500-mg dose, and this was

> just after 28 days, so the effect was relatively rapid as well, " she said.

>

> It is important to know that a supplement such as citicoline can affect

> attention without side effects, she added.

>

> Future work will determine the utility of citicoline in psychiatric

> disorders to see whether it will lessen some of the associated attention

> deficits that are associated with these disorders, Dr. McGlade said.

>

> *Large Potential Market*

>

> Citicoline is one of the few pyrimidines available as a nutritional

> supplement in the United States and Canada, noted Renshaw, MD, PhD,

> professor of psychiatry at the University of Utah, Salt Lake City.

>

> " Among other things, pyrimidines increase brain phospholipid synthesis,

> which is responsible for the therapeutic efficacy of citicoline as a

> treatment for stroke and head trauma, and they also increase catecholamine

> synthesis, which probably is responsible for citicoline's effect on

> attention, " said Dr. Renshaw, who was not part of the current study.

>

> " The study by McGlade and colleagues is significant in that it documents

> pro-attentional effects at a dose as low as 250 mg. Pharmaceutical doses as

> high as 4000 mg have been evaluated. If this effect can also be documented

> in other populations, such as children and teens, it suggests that

> citicoline would have a large market in the brain health area, " he said.

>

> *The study was funded by Kyowa Hakko Bio Co., Ltd, the manufacturers of the

> citicoline that was used in the study. Dr. McGlade has disclosed no relevant

> financial relationships. Dr. Renshaw has reported financial relationships

> with Ridge Diagnostics and Kyowa Hakko.*

>

> New Clinical Drug Evaluation Unit (NCDEU) 51st Annual Meeting, sponsored by

> the American Society of Clinical Psychopharmacology (ASCP). Abstract # 50.

> Presented June 14, 2011.www.medscape.com

> From Natural medicine

database:<http://naturaldatabase.therapeuticresearch.com>

> Editor's Comments: [image: return to

>

top]<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?rn=4 & cs= & s=ND\

& pt=100 & id=1090 & ds= & name=CITICOLINE & searchid=27875534#top>

> Citicoline was originally developed in Japan for acute cerebrovascular

> events. Citicoline was eventually introduced as a prescription drug in many

> European countries. In these countries it is now frequently prescribed for

> cognitive impairment related to chronic cerebrovascular disease . In the US

> citicoline is marketed as a dietary supplement and is often promoted for

> age-related cognitive impairment.

> --

> Ortiz, MS, RD

> *The FRUGAL Dietitian* <http://www.thefrugaldietitian.com>

> Check out my blog: mixture of deals and nutrition

> Join me on Facebook <http://www.facebook.com/TheFrugalDietitian?ref=ts>

>

> CONGRATS to my parents for 65 years of wedded bliss June 22,

> 1946<http://thefrugaldietitian.com/?p=22359>

> Join Crowdtap: Earn gift cards, try out products, support your charity…All

> for FREE!!! <http://thefrugaldietitian.com/?p=21973>Polo Shirt with your

> logo: $2.95 shipped <http://thefrugaldietitian.com/?p=20750> * " Nutrition is

> a Science, Not an Opinion Survey " *

>

>

>

[Guest guest]

The 1st time I heard of citicoline was last week from a patient that his family

doctor prescribed Somazina because he felt tired and with concentration

problems. I didn't have time yet to look more into it.

Patient experience: I took this for 1 month and didn't change anything.

" Citicoline (INN), also known as cytidine diphosphate-choline (CDP-Choline) &

cytidine 5'-diphosphocholine is a psychostimulant/nootropic. It is an

intermediate in the generation of phosphatidylcholine from choline. Sold in over

70 countries under a variety of brand names: Ceraxon, Cognizin, NeurAxon,

Somazina etc "

Catia Borges

>

> *My note: Never heard of it????*

>

> Citicoline, a naturally occurring substance found in the brain and liver and

> marketed as a nutritional supplement, enhanced aspects of cognition in

> healthy women and may have a role in mitigating the cognitive decline

> associated with normal aging, new research suggests.

>

> It may also improve the attention deficits associated with psychiatric

> disorders, said McGlade, PhD, from the University of Utah Brain

> Institute, Salt Lake City, who led the study.

>

> " We chose to study citicoline because in prior research it showed

> cognitive-enhancing effects with very few side effects, which is very

> important when using a supplement, " Dr. McGlade told *Medscape Medical News*

> .

>

> " We think these changes in cognition include improvement in attention,

> perhaps due to an increase in brain dopamine levels, but findings regarding

> dosing in healthy individuals have not been conclusive. "

>

> The study was presented here at the New Clinical Drug Evaluation Unit

> (NCDEU) 51st Annual Meeting, sponsored by the American Society of Clinical

> Psychopharmacology (ASCP).

>

> *Improvement 'Noteworthy' *

>

> Dr. McGlade and colleagues recruited 60 women age 40 to 60 years and

> screened them to rule out axis 1 or axis 2 psychiatric disorders, as well as

> any kind of cognitive deficits beyond the average cognitive decline

> associated with aging.

>

> The women were divided into 3 groups of 20 and randomly assigned to receive

> a daily oral citicoline dose of 250 mg (low dose) or 500 mg (high dose) or

> placebo for 28 days.

>

> They were evaluated with the Continuous Performance Test II (CPT-II) to

> measure attention functioning just after randomization and at the end of the

> study period.

>

> The investigators found that participants who received low- or high-dose

> citicoline showed improved attention, demonstrating fewer commission and

> omission errors on the CPT-II compared with the placebo group.

>

> " Women receiving the supplement made fewer errors in response to nontarget

> stimuli over the course of the study, " Dr. McGlade said.

>

> " Interestingly, the 250 dose produced similar results to the larger dose.

> The improvement was quite noteworthy, with a *P* value equal to .02 for the

> 250-mg dose and a *P* value equal to .03 with the 500-mg dose, and this was

> just after 28 days, so the effect was relatively rapid as well, " she said.

>

> It is important to know that a supplement such as citicoline can affect

> attention without side effects, she added.

>

> Future work will determine the utility of citicoline in psychiatric

> disorders to see whether it will lessen some of the associated attention

> deficits that are associated with these disorders, Dr. McGlade said.

>

> *Large Potential Market*

>

> Citicoline is one of the few pyrimidines available as a nutritional

> supplement in the United States and Canada, noted Renshaw, MD, PhD,

> professor of psychiatry at the University of Utah, Salt Lake City.

>

> " Among other things, pyrimidines increase brain phospholipid synthesis,

> which is responsible for the therapeutic efficacy of citicoline as a

> treatment for stroke and head trauma, and they also increase catecholamine

> synthesis, which probably is responsible for citicoline's effect on

> attention, " said Dr. Renshaw, who was not part of the current study.

>

> " The study by McGlade and colleagues is significant in that it documents

> pro-attentional effects at a dose as low as 250 mg. Pharmaceutical doses as

> high as 4000 mg have been evaluated. If this effect can also be documented

> in other populations, such as children and teens, it suggests that

> citicoline would have a large market in the brain health area, " he said.

>

> *The study was funded by Kyowa Hakko Bio Co., Ltd, the manufacturers of the

> citicoline that was used in the study. Dr. McGlade has disclosed no relevant

> financial relationships. Dr. Renshaw has reported financial relationships

> with Ridge Diagnostics and Kyowa Hakko.*

>

> New Clinical Drug Evaluation Unit (NCDEU) 51st Annual Meeting, sponsored by

> the American Society of Clinical Psychopharmacology (ASCP). Abstract # 50.

> Presented June 14, 2011.www.medscape.com

> From Natural medicine

database:<http://naturaldatabase.therapeuticresearch.com>

> Editor's Comments: [image: return to

>

top]<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?rn=4 & cs= & s=ND\

& pt=100 & id=1090 & ds= & name=CITICOLINE & searchid=27875534#top>

> Citicoline was originally developed in Japan for acute cerebrovascular

> events. Citicoline was eventually introduced as a prescription drug in many

> European countries. In these countries it is now frequently prescribed for

> cognitive impairment related to chronic cerebrovascular disease . In the US

> citicoline is marketed as a dietary supplement and is often promoted for

> age-related cognitive impairment.

> --

> Ortiz, MS, RD

> *The FRUGAL Dietitian* <http://www.thefrugaldietitian.com>

> Check out my blog: mixture of deals and nutrition

> Join me on Facebook <http://www.facebook.com/TheFrugalDietitian?ref=ts>

>

> CONGRATS to my parents for 65 years of wedded bliss June 22,

> 1946<http://thefrugaldietitian.com/?p=22359>

> Join Crowdtap: Earn gift cards, try out products, support your charity…All

> for FREE!!! <http://thefrugaldietitian.com/?p=21973>Polo Shirt with your

> logo: $2.95 shipped <http://thefrugaldietitian.com/?p=20750> * " Nutrition is

> a Science, Not an Opinion Survey " *

>

>

>