Vitamin D association with estradiol and progesterone in young women.

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Cancer Causes Control. <http://www.ncbi.nlm.nih.gov/pubmed/19916051#> 2010

Mar;21(3):479-83.

Vitamin D association with estradiol and progesterone in young women.

Knight

JA<http://www.ncbi.nlm.nih.gov/pubmed?term=%22Knight%20JA%22%5BAuthor%5D>,

Wong J <http://www.ncbi.nlm.nih.gov/pubmed?term=%22Wong%20J%22%5BAuthor%5D>,

Blackmore

KM<http://www.ncbi.nlm.nih.gov/pubmed?term=%22Blackmore%20KM%22%5BAuthor%5D>,

Raboud

JM<http://www.ncbi.nlm.nih.gov/pubmed?term=%22Raboud%20JM%22%5BAuthor%5D>,

Vieth R<http://www.ncbi.nlm.nih.gov/pubmed?term=%22Vieth%20R%22%5BAuthor%5D>

..

Source

Prosserman Centre for Health Research, Lunenfeld Research Institute,

Mount Sinai Hospital, Toronto, ON, Canada. knight@...

AbstractOBJECTIVE:

Vitamin D may reduce breast cancer risk through an effect on steroid

hormones in cycling women.We conducted a study to determine whether there is

an association between circulating 25-hydroxyvitamin D (25(OH)D) and

estradiol and progesterone in young women.

METHODS:

Volunteer women aged 18-22 and not using hormonal contraceptives were

recruited during summer and winter. They provided demographic and lifestyle

information and a blood sample. Women recruited in winter gave a second

sample after taking vitamin D supplement for 4 weeks. There were 101 women

sampled during the luteal phase (1-14 days prior to the start of the next

menstrual period). Generalized estimating equation linear regression models

were used to examine the relationship between 25(OH)D and estradiol and

progesterone.

RESULTS:

Per increase of 10 nmol/l of 25(OH)D, progesterone multiplicatively

decreased by a factor of 10% (95% CI 5-14%, p < 0.001) and estradiol

decreased by a factor of 3% (95% CI 0-6%, p = 0.04) after adjustment for

age, body mass index, ethnicity, season, alcohol use, smoking, and physical

activity.

CONCLUSIONS:

Higher levels of vitamin D may reduce progesterone and estradiol, providing

a potential mechanism for reduction in breast cancer risk from increased

vitamin D exposure in young women.

--

Ortiz, MS, RD

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