RESEARCH - Autoantibody explosion in antiphospholipid syndrome

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J Autoimmun. 2007 Dec 31 [Epub ahead of print]

Autoantibody explosion in antiphospholipid syndrome.

Shoenfeld Y, Twig G, Katz U, Sherer Y.

Department of Medicine 'B', Sheba Medical Center, Tel-Hashomer, Tel-Aviv

University, Israel; Center for Autoimmune Diseases, Sheba Medical Center,

Tel-Hashomer, Tel-Aviv University, Israel; Sackler Faculty of Medicine,

Tel-Aviv University, Israel.

Antiphospholipid syndrome (APS) is characterized by thrombosis and pregnancy

loss in the presence of antiphospholipid antibodies (aPL), mainly

anticardiolipin, anti-beta2-glycoprotein I and lupus anticoagulant. However,

similar to systemic lupus erythematosus, APS is also characterized by

multiple other autoantibodies including 'non-classical' aPL, as well as

other antibodies. Herein we describe the autoantigen properties, prevalence

and clinical importance of 30 different antibodies in APS. Among the other

antibodies characterizing APS are autoantibodies directed to platelets,

glycoproteins, various coagulation factors, lamins, mitochondrial antigens

and cell surface markers. Few of these autoantibodies are correlated with

the presence of other antibodies, and some may have an additive role in the

pro-thrombotic tendency of the syndrome. This autoantibody explosion might

be important in early identification of the syndrome and its manifestations.

PMID: 18171610

http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve & db=PubMed & list_uids=18

171610

Not an MD