Re: RESEARCH - The effect of individualized diet challenges consisting of allergenic foods on TNF and IL levels in patients with RA

[Guest guest]

i have some new hope for us poeple with ra. i was put on adderol 5mg xr, for

add. it actually seems to be helping me alot with patients, being more calm, and

most of all pain. this is something to consider. i had add when i was a child

but didnt realize it could follow you in adulthood. after seeing my pschologist,

for over 2 years we figured out im still suffering from add. check it out it is

worth it.

[ ] RESEARCH - The effect of individualized diet challenges

consisting of allergenic foods on TNF and IL levels in patients with RA

Rheumatology Advance Access originally published online on August 10, 2004

------------ --------- --------- --------- --------- --------- -

----

PAPER

The effect of individualized diet challenges consisting of allergenic foods

on TNF- and IL-1ß levels in patients with rheumatoid arthritis

S. Karatay1, T. Erdem2, K. Yildirim1, M. A. Melikoglu1, M. Ugur1, E. Cakir2,

F. Akcay3 and K. Senel1

Departments of 1 MD, Physical Medicine and Rehabilitation, 2 MD,

Dermatology, 3 MD, Biochemistry, Medical Faculty, Atatürk University,

Erzurum, Turkey.

Objective. To investigate the effect of individualized diet challenges

consisting of allergenic foods, defined by the skin prick test (SPT), on

tumour necrosis factor- (TNF-) and interleukin- 1ß (IL-1ß) levels in patients

with rheumatoid arthritis (RA).

Methods. Twenty patients with a positive SPT response for food extracts and

20 with a negative SPT response were enrolled. None of the patients had

active disease. All patients were fasted for the most common allergenic

foods for 12 days and then allocated to two groups according to SPT results.

Food challenges were performed with allergenic foods in the prick-positive

group (PPG) and with corn and rice in the prick-negative group (PNG) for a

period of 12 days. Then, allergenic foods were excluded from the PPG

patients’ diet and corn and rice were removed from the PNG patients’ diet.

Clinical examinations were performed after fasting (baseline), at the end of

the challenge phase and at the end of the re-elimination phase. Stiffness,

pain, tender and swollen joint counts, health assessment questionnaire

(HAQ), Ritchie's articular index, erythrocyte sedimentation rate (ESR),

C-reactive protein (CRP) and serum TNF- and IL-1ß levels were measured.

Results. TNF- (P<0.01), IL-1ß (P<0.05), ESR (P<0.05) and CRP (P = 0.001)

levels and all of the clinical variables, except HAQ, were increased with

food challenges in the PPG. These increases were also recorded after the

re-elimination phase. In the PNG, no significant change was seen in any of

the variables, except pain (P<0.05). During the study, important differences

were observed for most of the variables between the two groups. Thirteen

(72%) patients in the PPG and three (18%) in the PNG experienced disease

exacerbation with challenges. This aggravation continued after elimination.

Conclusions. Our results suggest that individualized dietary revisions may

regulate TNF- and IL-1ß levels in selected patients with RA.

************ ********* ********* ********* ********* *******

Read the entire article here:

http://rheumatology .oxfordjournals. org/cgi/content/ full/43/11/ 1429

Not an MD

________________________________________________________________________________\

____

Looking for last minute shopping deals?

Find them fast with Search.

http://tools.search./newsearch/category.php?category=shopping