Re: IgG Food Intolerance Tests: What does the science say?

[Guest guest]

Take the time to read the comments. Lovely, entertaining, and enlightening!!!

 

Holly

---------- Holly Lee Brewer, MS RD Pediatric Dietitian, Diabetes Educator

Medical Nutrition Therapist, Las Vegas, NV Maj Holly Brewer, USAFR BSC 301st

MDS, NAS JRB Fort Worth (Carswell), TX http://hollyinbalad.blogspot.com

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>To: RD-USA <rd-usa >

>Sent: Saturday, February 4, 2012 7:31 PM

>Subject: IgG Food Intolerance Tests: What does the science say?

>

>

> 

>Link<http://www.sciencebasedmedicine.org/index.php/igg-food-intolerance-tests-w\

hat-does-the-science-say/>

>

>--

> Ortiz, MS, RD

>The Frugal Dietitian <http://www.thefrugaldietitian.com>

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[Guest guest]

 The problem with IgG testing is that elevated IgG levels can simply indicate

frequent consumption, and is not necessarily correlated with an adverse immune

response.    Also, many of the conditions that we frequently see (irritable

bowel syndrome, migraine, ulcerative colitis, etc are more associated with

T-cell mediated reactions, not IgG.     Here's one abstract for example:  

Am J Gastroenterol. 2009 May;104(5):1205-12. Epub 2009 Apr 14.

T-cell activation in patients with irritable bowel syndrome.

Ohman L, Isaksson S, Lindmark AC, Posserud I, Stotzer PO, Strid H, Sjövall

H, Simrén M.

Source

Department of Internal Medicine, Institute of Medicine, The Sahlgren's Academy,

University of Gothenburg, Gothenburg, Sweden. lena.ohman@...

Abstract

OBJECTIVES:

Irritable bowel syndrome (IBS) has been found to be associated with low-grade

immune activation in a subset of patients. We therefore investigated blood and

colonic T-cell activity in IBS patients.

METHODS:

Blood samples were initially obtained from 74 IBS patients and 30 controls.

Supplementary blood samples, to confirm data, were taken from another cohort (26

patients and 14 controls). In addition, colonic biopsies were taken from a third

cohort (11 patients and 10 controls). Peripheral blood and colonic mononuclear

cells were stimulated with anti-CD3/CD28 antibodies. Proliferation, cytokine

secretion, and T-cell phenotype were investigated. IBS symptom severity was

assessed.

RESULTS:

IBS patients displayed an activated phenotype with increased frequencies of

blood T cells expressing CD69 and integrin beta7/HLA-DR.

Anti-CD3/CD28-stimulated blood and colonic T cells from IBS patients

proliferated less than T cells from controls. IBS patients had an increased

polyclonally stimulated T-cell secretion of IL-1beta, which also weakly

correlated with increased bowel habit dissatisfaction. Furthermore, despite

normal frequencies of CD25high T cells in the blood of IBS patients, lower blood

CD25high T-cell frequencies were modestly correlated with more bowel habit

dissatisfaction and increased total IBS symptom severity.

CONCLUSIONS:

IBS patients have an increased frequency of activated T cells, demonstrated by

the expression of activation markers and reduced proliferation in response to

restimulation in vitro. The increased level of T-cell activation is consistent

with the hypothesis of low-grade immune activation in IBS and may also be

involved in symptom generation in IBS.

Linke, MS RD LD CLT

Certified LEAP Therapist

Dallas, TX 

>________________________________

>

>To: RD-USA <rd-usa >

>Sent: Saturday, February 4, 2012 7:31 PM

>Subject: IgG Food Intolerance Tests: What does the science say?

>

>Link<http://www.sciencebasedmedicine.org/index.php/igg-food-intolerance-tests-w\

hat-does-the-science-say/>

>

>--

> Ortiz, MS, RD

>The Frugal Dietitian <http://www.thefrugaldietitian.com>

>Check out my blog: mixture of deals and nutrition

>Join me on Facebook <http://www.facebook.com/TheFrugalDietitian?ref=ts>

>Join me on Twitter <http://twitter.com/frugaldietitian>

>

>

>