REVIEW - Anti-inflammatory and immunosuppressive drugs and reproduction

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Arthritis Res Ther. 2006; 8(3): 209.

Published online 2006 May 11. doi: 10.1186/ar1957. PMCID: PMC1526635

Anti-inflammatory and immunosuppressive drugs and reproduction

Monika Østensen,1 Munther Khamashta,2 Lockshin,3 Ann Parke,4

Brucato,5 Carp,6 Doria,7 Raj Rai,8 Pierluigi

Meroni,9 Irene Cetin,10 Derksen,11 Ware Branch,12

Motta,13 Caroline Gordon,14 Guillermo Ruiz-Irastorza,15 Arsenio

Spinillo,16 Deborah Friedman,17 Rolando Cimaz,18 Czeizel,19

Piette,20 Ricard Cervera,21 A Levy,22 Maurizio

Clementi,23 Sara De Carolis,23 Petri,24 Yehuda Shoenfeld,25

Faden,26,29 Guido Valesini,27 and Tincani28

1Department of Rheumatology and Clinical Immunology/Allergology,

University Hospital of Bern, Switzerland

2Lupus Research Unit, The Rayne Institute, St ' Hospital, London, UK

3Joan and Sanford Weill College of Medicine of Cornell University,

Barbara Volcker Center for Women and Rheumatic Disease, Hospital for

Special Surgery, New York, USA

4Division of Rheumatic Diseases, Department of Medicine, University of

Connecticut Health Center, Farmington, USA

5Department of Internal Medicine and Rheumatology, Niguarda Hospital,

Milano, Italy

6Department of Obstetrics and Gynecology, Sheba Medical Center, Tel

Hashomer, Israel, and Tel Aviv University, Israel

7Division of Rheumatology, Department of Clinical and Experimental

Medicine, University of Padova, Italy

8Department of Obstetrics and Gynaecology, Imperial College School of

Medicine, London, UK

9Cattedra di Medicina Interna, University of Milano, Italy

10Institute of Obstetrics and Gynecology, L Mangiagalli, University of

Milano, Italy

11Department of Rheumatology and Clinical Immunology, University

Medical Centre Utrecht, The Netherlands

12Department of Obstetrics and Gynecology, The University of Utah

Health Sciences Center, Salt Lake City, Utah, USA

13Neonatology and Neonatal Intensive Care Unit, Spedali Civili, Brescia, Italy

14Centre for Immune Regulation, Division of Immunity and Infection,

The University of Birmingham, Birmingham, UK

15Department of Internal Medicine, Hospital de Cruces, University of

The Basque Country, Bizkaia, Spain

16Department of Obstetrics and Gynecology, University of Pavia, Italy

17University of Texas, Health Science Center, Houston, USA

18Pediatrics, Fondazione Policlinico Mangiagalli, Milano, Italy

19Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary

20Service de Médecine Interne, Groupe Hospitalier Pitié-Salpêtrière,

Paris, France

21Department of Autoimmune Diseases, Hospital Clínic, Barcelona,

Catalonia, Spain

22Discipline of Rheumatology, Faculdades de Ciencias Medicas,

Universidade do Estado do Rio de Janeiro, Brazil

23Department of Obstetrics and Gynecology, Catholic University of

Sacred Heart, Rome, Italy

24Lupus Center, s Hopkins University School of Medicine, Division

of Rheumatology, Baltimore, USA

25Department of Medicine and Center for Autoimmune Diseases, Sheba

Medical Center, Tel-Aviv University, Tel-Hashomer, Israel

26Obstetric and Gynecology Department, University and Hospital of Brescia, Italy

27Cattedra di Reumatologia, Università 'La Sapienza', Roma, Italy

28Rheumatology and Clinical Immunology, University and Hospital of

Brescia, Italy

29Deceased in 2005

Corresponding author.

Monika Østensen: monika.oestensen@...

This article has been cited by other articles in PMC.

Abstract

Rheumatic diseases in women of childbearing years may necessitate drug

treatment during a pregnancy, to control maternal disease activity and

to ensure a successful pregnancy outcome. This survey is based on a

consensus workshop of international experts discussing effects of

anti-inflammatory, immunosuppressive and biological drugs during

pregnancy and lactation. In addition, effects of these drugs on male

and female fertility and possible long-term effects on infants exposed

to drugs antenatally are discussed where data were available.

Recommendations for drug treatment during pregnancy and lactation are

given.

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http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1526635

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