PR on DMAA (safe?, not unsafe? manipulated?)

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press release

Dec. 8, 2011, 10:54 a.m. EST

Newly Released, Groundbreaking Research Studies Show USPlabs' DMAA

Supplements are Safe and Effective

DALLAS, Dec. 8, 2011 /PRNewswire via COMTEX/ -- Four new medical

research studies published today and one more to come confirm that the

best-selling supplements produced by USPlabs, Jack3d and OxyElite Pro,

which contain DMAA, are safe and do not cause adverse health effects

when used as directed, according to the research on DMAA conducted by a

leading medical expert on nutritional supplements.

The groundbreaking, peer-reviewed studies on the DMAA products were

performed at an esteemed cardiorespiratory laboratory at a Division I,

U.S. university by one of the nation's leading and most respected

experts on nutritional supplements.

The release of these studies places both Jack3d and OxyElite Pro in the

top 1% for volume of medical research performed on finished dietary

supplements. The studies were undertaken in order to reiterate the

safety of products containing DMAA through medical research and the

results show that DMAA-containing products can be a safe and effective

part of a healthy workout regimen.

The results of the studies are as follows.

Study #1: OxyElite Pro Acute Study

In a randomized, double-blind and placebo-controlled trial with

crossover, OxyElite Pro was shown to increase markers of lipolysis (fat

breakdown) and energy expenditure (metabolic rate) in a group of six

healthy men and six healthy women, all of whom were exercise-trained

individuals.

Specifically for the markers of lipolysis, glycerol was increased by an

average of 29% and 65% over baseline in men and women, respectively, 120

minutes after ingesting two capsules of OxyElite Pro. Free fatty acids

were increased by an average of 92% and 68% in men and women,

respectively. Finally, energy expenditure was increased by an average of

9% and 24% in men and women, respectively.

These data indicate that by increasing lipolysis and metabolic rate, the

DMAA-containing OxyElite Pro may allow for reduced fat mass and weight

loss.

Link:

http://www.la-press.com/a-finished-dietary-supplement-stimulates-lipolys

is-and-metabolic-rate--article-a2945

Study #2: OxyElite Pro Eight-Week Safety & Efficacy Study

In a randomized, double-blind, placebo-controlled trial, OxyElite Pro

was studied to see if it could improve body composition in healthy men

and women over an eight-week period of use. A group of 32

exercise-trained men and women participated in the study. When comparing

baseline values with those after eight weeks of use, subjects in the

OxyElite Pro group were found to have decreased body weight, BMI, waist

size, waist to hip ratio, total body fat percentage, fat mass and

appetite.

In addition to efficacy, safety of the DMAA-containing product was also

assessed via hemodynamic and metabolic variables. While OxyElite did

increase heart rate by an average of six beats per minute (comparable to

the effect seen in some studies after the administration of caffeine

dosages equivalent to 2 or 3 cups of coffee), no changes in blood

pressure were noted when comparing the values seen at baseline to those

after eight weeks of use. In addition, liver and kidney function were

not affected as indicated by various blood borne markers. The supplement

was well-tolerated and no serious adverse events were noted.

In looking at the product's efficacy, men experienced an average 1.16%

reduction in body fat percentage while women experienced an average

decrease of 0.8%. Men experienced a 1.24 inch reduction in their waist

size from baseline, while women lost 0.78 inches. Men also lost 0.92

inches off their hips while the women's hip sizes didn't change,

indicating an improvement of the waist-hip ratio.

Men's fat mass decreased by 3.86 lb from baseline while women's fat mass

decreased 1.9 lb. Men's body weight decreased by an average of 5.06 lb

from baseline while women's decreased 3.36 lb.

In addition, when subjects were asked to rate their appetite on a scale

of 1-10 from baseline until week eight of the study, they reported an

average decrease in appetite scores of approximately 24% after using

OxyElite Pro.

Overall, this eight-week study corroborated what the previous acute

study indicated, which is that by increasing lipolysis and metabolic

rate, OxyElite Pro is able to reduce fat mass in healthy men and women.

Link:

http://www.la-press.com/biochemical-and-anthropometric-effects-of-a-weig

ht-loss-dietary-supple-article-a2946

Study #3: Jack3d Two-Week Safety Study

In an open-label, single-arm trial consisting of seven healthy men, each

was instructed to consume the DMAA-containing Jack3d each day for two

weeks. At the beginning and end of the study, blood pressure, heart rate

and various indicators of renal and liver function were assessed. The

study found that there were no statistically significant changes from

baseline to the end of the study. Jack3d, which contains DMAA, was well

tolerated and no serious adverse events were noted.

In addition to these data, the hemodynamic response to acute ingestion

was assessed as well for this DMAA product. Although small and transient

changes in blood pressure were noted, these changes were consistent with

changes seen after administration of the equivalent of 2-3 cups of

coffee. Jack3d did not result in a statistically significant change in

heart rate or blood pressure.

Link:

http://www.la-press.com/hemodynamic-and-hematologic-profile-of-healthy-a

dults-ingesting-dietar-article-a2947

Study #4: OxyElite Pro Two-Week Safety Study

In an open-label, single-arm trial consisting of four men and two women,

subjects were instructed to consume OxyElite Pro each day for two weeks.

At the beginning and end of the study, blood pressure, heart rate and

various indicators of renal and liver function were assessed. The study

found that there were no statistically significant changes from baseline

to the end of the study. No serious adverse events were noted.

In addition to these data, the hemodynamic response to acute ingestion

was assessed as well. OxyElite Pro did not result in a statistically

significant change in heart rate or diastolic pressure, but did cause a

statistically significant change in systolic blood pressure; this

increase was mild and transient and yet again, was similar to the

increase seen in subjects ingesting an amount of caffeine equivalent to

2-3 cups of coffee.

Link:

http://www.la-press.com/hemodynamic-and-hematologic-profile-of-healthy-a

dults-ingesting-dietar-article-a2947

Study #5: Jack3d Ten-Week Safety Study

In addition, a ten-week safety study on the DMAA-containing Jack3d has

been submitted for publication. This study evaluated heart rate, blood

pressure and various measures of metabolic function (e.g., liver and

kidney function) and found no changes from baseline to the end of the

study. Jack3d was well tolerated and no adverse effects were noted.

SOURCE USPlabs

Copyright © 2011 PR Newswire. All rights reserved

S. Kalman PhD, RD, FACN

Director, BD - Nutrition & Applied Clinical Trials

Miami Research Associates

6141 Sunset Drive

Suite 301

Miami, FL. 33143

Direct -

Office ext. 5109

Fax

Email: dkalman@...

Web: www.miamiresearch.com

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